Combinatorial targeting of early pathways profoundly inhibits neurodegeneration in a mouse model of glaucoma

The endothelin system is implicated in various human and animal glaucomas. Targeting the endothelin system has great promise as a treatment for human glaucoma, but the cell types involved and the exact mechanisms of action are not clearly elucidated. Here, we report a detailed characterization of th...

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Hlavní autoři: Gareth R. Howell, Katharine H. MacNicoll, Catherine E. Braine, Ileana Soto, Danilo G. Macalinao, Gregory L. Sousa, Simon W.M. John
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2014-11-01
Edice:Neurobiology of Disease
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On-line přístup:http://www.sciencedirect.com/science/article/pii/S0969996114002381