Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism.
The response of parameters of plasma cholesterol metabolism was studied in baboons adapted either to a low-fat, low-cholesterol diet or a high-fat, high-cholesterol diet. Animals adapted to the low-fat diet responded to a single low-fat or high-fat meal, as do normal humans, by a stimulation of chol...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
1989-08-01
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| Series: | Journal of Lipid Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520382791 |
| _version_ | 1818590255169667072 |
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| author | P E Fielding E M Jackson C J Fielding |
| author_facet | P E Fielding E M Jackson C J Fielding |
| author_sort | P E Fielding |
| collection | DOAJ |
| description | The response of parameters of plasma cholesterol metabolism was studied in baboons adapted either to a low-fat, low-cholesterol diet or a high-fat, high-cholesterol diet. Animals adapted to the low-fat diet responded to a single low-fat or high-fat meal, as do normal humans, by a stimulation of cholesterol transport from blood cells to plasma, a stimulation of esterification of cholesterol, and a stimulation of cholesteryl ester transfer to very low and low density lipoproteins. While fasting rates of esterification and transfer increased as a result of diet-induced hypercholesterolemia, the postprandial response was reversed, so that postprandial metabolism was characterized by a movement of cholesterol from plasma to blood cells, an inhibition of cholesterol esterification, and a net transfer of cholesteryl esters from VLDL and LDL to HDL. These data indicate that the effects of postprandial lipemia on plasma cholesterol metabolism critically depend upon fasting plasma cholesterol levels. |
| first_indexed | 2024-12-16T09:53:38Z |
| format | Article |
| id | doaj.art-077f8216629441c1a20f6a48f8dbaefe |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T09:53:38Z |
| publishDate | 1989-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-077f8216629441c1a20f6a48f8dbaefe2022-12-21T22:35:58ZengElsevierJournal of Lipid Research0022-22751989-08-0130812111217Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism.P E Fielding0E M Jackson1C J Fielding2Cardiovascular Research Institute, University of California, San Francisco.Cardiovascular Research Institute, University of California, San Francisco.Cardiovascular Research Institute, University of California, San Francisco.The response of parameters of plasma cholesterol metabolism was studied in baboons adapted either to a low-fat, low-cholesterol diet or a high-fat, high-cholesterol diet. Animals adapted to the low-fat diet responded to a single low-fat or high-fat meal, as do normal humans, by a stimulation of cholesterol transport from blood cells to plasma, a stimulation of esterification of cholesterol, and a stimulation of cholesteryl ester transfer to very low and low density lipoproteins. While fasting rates of esterification and transfer increased as a result of diet-induced hypercholesterolemia, the postprandial response was reversed, so that postprandial metabolism was characterized by a movement of cholesterol from plasma to blood cells, an inhibition of cholesterol esterification, and a net transfer of cholesteryl esters from VLDL and LDL to HDL. These data indicate that the effects of postprandial lipemia on plasma cholesterol metabolism critically depend upon fasting plasma cholesterol levels.http://www.sciencedirect.com/science/article/pii/S0022227520382791 |
| spellingShingle | P E Fielding E M Jackson C J Fielding Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism. Journal of Lipid Research |
| title | Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism. |
| title_full | Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism. |
| title_fullStr | Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism. |
| title_full_unstemmed | Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism. |
| title_short | Chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism. |
| title_sort | chronic dietary fat and cholesterol inhibit the normal postprandial stimulation of plasma cholesterol metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520382791 |
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