Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection

Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a severe global pandemic. Mice models are essential to investigate infection pathology, antiviral drugs, and vaccine development. However, wild-type mice lack the human angiotensin-converting enzyme 2 (hACE2) that mediates SARS-CoV-...

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Bibliographic Details
Main Authors: Chaja Katzman, Tomer Israely, Sharon Melamed, Boaz Politi, Assa Sittner, Yfat Yahalom-Ronen, Shay Weiss, Reem Abu Rass, Rachel Zamostiano, Eran Bacharach, Marcelo Ehrlich, Nir Paran, Lior Nissim
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
hACE2
lentivirus
mouse model
immune response
Online Access:https://www.mdpi.com/1999-4915/14/1/11

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