Associations between APOE variants and metabolic traits and the impact of psychological stress.
In a previous study, we observed that associations between APOE rs439401 and metabolic traits were moderated by chronic stress. Thus, in a population of stressed and non-stressed Danish men, we examined whether associations between APOE rs439401 and a panel of metabolic quantitative traits, all meta...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2011-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3023763?pdf=render |
| _version_ | 1819125791098667008 |
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| author | Sofia I Iqbal Kring John Barefoot Beverly H Brummett Stephen H Boyle Ilene C Siegler Søren Toubro Torben Hansen Arne Astrup Oluf Pedersen Redford B Williams Thorkild I A Sørensen |
| author_facet | Sofia I Iqbal Kring John Barefoot Beverly H Brummett Stephen H Boyle Ilene C Siegler Søren Toubro Torben Hansen Arne Astrup Oluf Pedersen Redford B Williams Thorkild I A Sørensen |
| author_sort | Sofia I Iqbal Kring |
| collection | DOAJ |
| description | In a previous study, we observed that associations between APOE rs439401 and metabolic traits were moderated by chronic stress. Thus, in a population of stressed and non-stressed Danish men, we examined whether associations between APOE rs439401 and a panel of metabolic quantitative traits, all metabolic traits which may lead to T2D and CVD were moderated by psychological stress.Obese young men (n = 475, BMI ≥ 31.0 kg/m(2)) and a randomly selected control group (n = 709) identified from a population of 141,800 men were re-examined in two surveys (S-46: mean age 46, S-49: mean age 49 years) where anthropometric and biochemical measures were available. Psychological stress factors were assessed by a self-administered 7-item questionnaire. Each item had the possible response categories "yes" and "no" and assessed familial problems and conflicts. Summing positive responses constituted a stress item score, which was then dichotomized into stressed and non-stressed. Logistic regression analysis, applying a recessive genetic model, was used to assess odds ratios (OR) of the associations between APOE rs439401 genotypes and adverse levels of metabolic traits.The APOE rs439401 TT-genotype associated positively with BMI (OR = 1.09 [1.01; 1.17]), waist circumference (OR = 1.09 [1.02; 1.17]) in stressed men at S-46. Positive associations were observed for fasting plasma glucose (OR = 1.42 [1.07; 1.87]), serum triglycerides (OR = 1.41 [1.05; 1.91]) and with fasting plasma insulin (OR = 1.48 [1.05; 2.08]) in stressed men at S-49. Rs439401 TT-genotype also associated positively with surrogate measures of insulin resistance (HOMA-IR; OR = 1.21 [1.03; 1.41]) and inversely with insulin sensitivity (Stumvoll index; OR = 0.90 [0.82; 0.99], BIGTT-S(I); OR = 0.60 [0.43; 0.85]) in stressed men. No significant associations were observed in non-stressed men, albeit the estimates showed similar but weaker trends as in stressed men.The present results suggest that the APOE rs439401 TT-genotype is associated with an adverse metabolic profile in a population of psychologically stressed Danish men. |
| first_indexed | 2024-12-22T07:45:45Z |
| format | Article |
| id | doaj.art-0780d101fe85474bbec9b4d0a0a0a351 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T07:45:45Z |
| publishDate | 2011-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj.art-0780d101fe85474bbec9b4d0a0a0a3512022-12-21T18:33:38ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-01-0161e1574510.1371/journal.pone.0015745Associations between APOE variants and metabolic traits and the impact of psychological stress.Sofia I Iqbal KringJohn BarefootBeverly H BrummettStephen H BoyleIlene C SieglerSøren ToubroTorben HansenArne AstrupOluf PedersenRedford B WilliamsThorkild I A SørensenIn a previous study, we observed that associations between APOE rs439401 and metabolic traits were moderated by chronic stress. Thus, in a population of stressed and non-stressed Danish men, we examined whether associations between APOE rs439401 and a panel of metabolic quantitative traits, all metabolic traits which may lead to T2D and CVD were moderated by psychological stress.Obese young men (n = 475, BMI ≥ 31.0 kg/m(2)) and a randomly selected control group (n = 709) identified from a population of 141,800 men were re-examined in two surveys (S-46: mean age 46, S-49: mean age 49 years) where anthropometric and biochemical measures were available. Psychological stress factors were assessed by a self-administered 7-item questionnaire. Each item had the possible response categories "yes" and "no" and assessed familial problems and conflicts. Summing positive responses constituted a stress item score, which was then dichotomized into stressed and non-stressed. Logistic regression analysis, applying a recessive genetic model, was used to assess odds ratios (OR) of the associations between APOE rs439401 genotypes and adverse levels of metabolic traits.The APOE rs439401 TT-genotype associated positively with BMI (OR = 1.09 [1.01; 1.17]), waist circumference (OR = 1.09 [1.02; 1.17]) in stressed men at S-46. Positive associations were observed for fasting plasma glucose (OR = 1.42 [1.07; 1.87]), serum triglycerides (OR = 1.41 [1.05; 1.91]) and with fasting plasma insulin (OR = 1.48 [1.05; 2.08]) in stressed men at S-49. Rs439401 TT-genotype also associated positively with surrogate measures of insulin resistance (HOMA-IR; OR = 1.21 [1.03; 1.41]) and inversely with insulin sensitivity (Stumvoll index; OR = 0.90 [0.82; 0.99], BIGTT-S(I); OR = 0.60 [0.43; 0.85]) in stressed men. No significant associations were observed in non-stressed men, albeit the estimates showed similar but weaker trends as in stressed men.The present results suggest that the APOE rs439401 TT-genotype is associated with an adverse metabolic profile in a population of psychologically stressed Danish men.http://europepmc.org/articles/PMC3023763?pdf=render |
| spellingShingle | Sofia I Iqbal Kring John Barefoot Beverly H Brummett Stephen H Boyle Ilene C Siegler Søren Toubro Torben Hansen Arne Astrup Oluf Pedersen Redford B Williams Thorkild I A Sørensen Associations between APOE variants and metabolic traits and the impact of psychological stress. PLoS ONE |
| title | Associations between APOE variants and metabolic traits and the impact of psychological stress. |
| title_full | Associations between APOE variants and metabolic traits and the impact of psychological stress. |
| title_fullStr | Associations between APOE variants and metabolic traits and the impact of psychological stress. |
| title_full_unstemmed | Associations between APOE variants and metabolic traits and the impact of psychological stress. |
| title_short | Associations between APOE variants and metabolic traits and the impact of psychological stress. |
| title_sort | associations between apoe variants and metabolic traits and the impact of psychological stress |
| url | http://europepmc.org/articles/PMC3023763?pdf=render |
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