Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA
Powassan virus, a member of the tick-borne encephalitis group of flaviviruses, encompasses 2 lineages with separate enzootic cycles. The prototype lineage of Powassan virus (POWV) is principally maintained between Ixodes cookei ticks and the groundhog (Marmota momax) or striped skunk (Mephitis mephi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Centers for Disease Control and Prevention
2013-12-01
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| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/19/12/13-0903_article |
| _version_ | 1811263864940003328 |
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| author | Marc Y. El Khoury Jose F. Camargo Jennifer L. White Bryon P. Backenson Alan P. Dupuis Kay L. Escuyer Laura Kramer Kirsten St. George Debarati Chatterjee Melissa Prusinski Gary P. Wormser Susan J. Wong |
| author_facet | Marc Y. El Khoury Jose F. Camargo Jennifer L. White Bryon P. Backenson Alan P. Dupuis Kay L. Escuyer Laura Kramer Kirsten St. George Debarati Chatterjee Melissa Prusinski Gary P. Wormser Susan J. Wong |
| author_sort | Marc Y. El Khoury |
| collection | DOAJ |
| description | Powassan virus, a member of the tick-borne encephalitis group of flaviviruses, encompasses 2 lineages with separate enzootic cycles. The prototype lineage of Powassan virus (POWV) is principally maintained between Ixodes cookei ticks and the groundhog (Marmota momax) or striped skunk (Mephitis mephitis), whereas the deer tick virus (DTV) lineage is believed to be maintained between Ixodes scapularis ticks and the white-footed mouse (Peromyscus leucopus). We report 14 cases of Powassan encephalitis from New York during 2004–2012. Ten (72%) of the patients were residents of the Lower Hudson Valley, a Lyme disease–endemic area in which I. scapularis ticks account for most human tick bites. This finding suggests that many of these cases were caused by DTV rather than POWV. In 2 patients, DTV infection was confirmed by genetic sequencing. As molecular testing becomes increasingly available, more cases of Powassan encephalitis may be determined to be attributable to the DTV lineage. |
| first_indexed | 2024-04-12T19:52:48Z |
| format | Article |
| id | doaj.art-078176a9360e4c4385ee74b872b809aa |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-04-12T19:52:48Z |
| publishDate | 2013-12-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-078176a9360e4c4385ee74b872b809aa2022-12-22T03:18:46ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60592013-12-0119121926193310.3201/eid1912.130903Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USAMarc Y. El KhouryJose F. CamargoJennifer L. WhiteBryon P. BackensonAlan P. DupuisKay L. EscuyerLaura KramerKirsten St. GeorgeDebarati ChatterjeeMelissa PrusinskiGary P. WormserSusan J. WongPowassan virus, a member of the tick-borne encephalitis group of flaviviruses, encompasses 2 lineages with separate enzootic cycles. The prototype lineage of Powassan virus (POWV) is principally maintained between Ixodes cookei ticks and the groundhog (Marmota momax) or striped skunk (Mephitis mephitis), whereas the deer tick virus (DTV) lineage is believed to be maintained between Ixodes scapularis ticks and the white-footed mouse (Peromyscus leucopus). We report 14 cases of Powassan encephalitis from New York during 2004–2012. Ten (72%) of the patients were residents of the Lower Hudson Valley, a Lyme disease–endemic area in which I. scapularis ticks account for most human tick bites. This finding suggests that many of these cases were caused by DTV rather than POWV. In 2 patients, DTV infection was confirmed by genetic sequencing. As molecular testing becomes increasingly available, more cases of Powassan encephalitis may be determined to be attributable to the DTV lineage.https://wwwnc.cdc.gov/eid/article/19/12/13-0903_articledeer tick virusPowassan virusencephalitisflavivirusIxodes scapularisNew York |
| spellingShingle | Marc Y. El Khoury Jose F. Camargo Jennifer L. White Bryon P. Backenson Alan P. Dupuis Kay L. Escuyer Laura Kramer Kirsten St. George Debarati Chatterjee Melissa Prusinski Gary P. Wormser Susan J. Wong Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA Emerging Infectious Diseases deer tick virus Powassan virus encephalitis flavivirus Ixodes scapularis New York |
| title | Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA |
| title_full | Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA |
| title_fullStr | Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA |
| title_full_unstemmed | Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA |
| title_short | Potential Role of Deer Tick Virus in Powassan Encephalitis Cases in Lyme Disease–endemic Areas of New York, USA |
| title_sort | potential role of deer tick virus in powassan encephalitis cases in lyme disease endemic areas of new york usa |
| topic | deer tick virus Powassan virus encephalitis flavivirus Ixodes scapularis New York |
| url | https://wwwnc.cdc.gov/eid/article/19/12/13-0903_article |
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