A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are uncommon but life-threatening diseases mostly caused by drugs. Although various systemic immunomodulating agents have been used, their therapeutic efficacy has been inconsistent. This study aimed to provide an evidence-based rev...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2105 |
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| author | Hua-Ching Chang Tsung-Jen Wang Ming-Hsiu Lin Ting-Jui Chen |
| author_facet | Hua-Ching Chang Tsung-Jen Wang Ming-Hsiu Lin Ting-Jui Chen |
| author_sort | Hua-Ching Chang |
| collection | DOAJ |
| description | Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are uncommon but life-threatening diseases mostly caused by drugs. Although various systemic immunomodulating agents have been used, their therapeutic efficacy has been inconsistent. This study aimed to provide an evidence-based review of systemic immunomodulating treatments for SJS/TEN. We reviewed 13 systematic review and meta-analysis articles published in the last 10 years. The use of systemic corticosteroids and IVIg is still controversial. An increasing number of studies have suggested the effectiveness of cyclosporine and biologic anti-TNF-α in recent years. There were also some promising results of combination treatments. Further large-scale randomized controlled trials are required to provide more definitive evidence of the effectiveness of these treatments. The pathogenesis of SJS/TEN has been elucidated in recent years and advances in the understanding of SJS/TEN may inspire the discovery of potential therapeutic targets. |
| first_indexed | 2024-03-10T00:39:54Z |
| format | Article |
| id | doaj.art-0782e60328244fcf848719a770a2eb99 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:39:54Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-0782e60328244fcf848719a770a2eb992023-11-23T15:09:14ZengMDPI AGBiomedicines2227-90592022-08-01109210510.3390/biomedicines10092105A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal NecrolysisHua-Ching Chang0Tsung-Jen Wang1Ming-Hsiu Lin2Ting-Jui Chen3Department of Dermatology, School of Medicine, College of Medicine, Taipei Medical University Hospital and Taipei Medical University, Taipei 11031, TaiwanDepartment of Ophthalmology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, TaiwanDepartment of Dermatology, School of Medicine, College of Medicine, Taipei Medical University Hospital and Taipei Medical University, Taipei 11031, TaiwanDepartment of Dermatology, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan 33004, TaiwanStevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are uncommon but life-threatening diseases mostly caused by drugs. Although various systemic immunomodulating agents have been used, their therapeutic efficacy has been inconsistent. This study aimed to provide an evidence-based review of systemic immunomodulating treatments for SJS/TEN. We reviewed 13 systematic review and meta-analysis articles published in the last 10 years. The use of systemic corticosteroids and IVIg is still controversial. An increasing number of studies have suggested the effectiveness of cyclosporine and biologic anti-TNF-α in recent years. There were also some promising results of combination treatments. Further large-scale randomized controlled trials are required to provide more definitive evidence of the effectiveness of these treatments. The pathogenesis of SJS/TEN has been elucidated in recent years and advances in the understanding of SJS/TEN may inspire the discovery of potential therapeutic targets.https://www.mdpi.com/2227-9059/10/9/2105Stevens–Johnson syndrometoxic epidermal necrolysismeta-analysis |
| spellingShingle | Hua-Ching Chang Tsung-Jen Wang Ming-Hsiu Lin Ting-Jui Chen A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Biomedicines Stevens–Johnson syndrome toxic epidermal necrolysis meta-analysis |
| title | A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis |
| title_full | A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis |
| title_fullStr | A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis |
| title_full_unstemmed | A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis |
| title_short | A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis |
| title_sort | review of the systemic treatment of stevens johnson syndrome and toxic epidermal necrolysis |
| topic | Stevens–Johnson syndrome toxic epidermal necrolysis meta-analysis |
| url | https://www.mdpi.com/2227-9059/10/9/2105 |
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