Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis.
BACKGROUND AND OBJECTIVES: We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF). METHODS: In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous br...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4164356?pdf=render |
| _version_ | 1818177700922130432 |
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| author | Markus Wettstein Lorenz Radlinger Thomas Riedel |
| author_facet | Markus Wettstein Lorenz Radlinger Thomas Riedel |
| author_sort | Markus Wettstein |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVES: We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF). METHODS: In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed. RESULTS: The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP. CONCLUSIONS: PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy. |
| first_indexed | 2024-12-11T20:36:16Z |
| format | Article |
| id | doaj.art-0783440547814e4abbf99a09f04f1bac |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-11T20:36:16Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-0783440547814e4abbf99a09f04f1bac2022-12-22T00:51:39ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10659110.1371/journal.pone.0106591Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis.Markus WettsteinLorenz RadlingerThomas RiedelBACKGROUND AND OBJECTIVES: We investigated the effect of different breathing aids on ventilation distribution in healthy adults and subjects with cystic fibrosis (CF). METHODS: In 11 healthy adults and 9 adults with CF electrical impedance tomography measurements were performed during spontaneous breathing, continuous positive airway pressure (CPAP) and positive expiratory pressure (PEP) therapy randomly applied in upright and lateral position. Spatial and temporal ventilation distribution was assessed. RESULTS: The proportion of ventilation directed to the dependent lung significantly increased in lateral position compared to upright in healthy and CF. This effect was enhanced with CPAP but neutralised with PEP, whereas the effect of PEP was larger in the healthy group. Temporal ventilation distribution showed exactly the opposite with homogenisation during CPAP and increased inhomogeneity with PEP. CONCLUSIONS: PEP shows distinct differences to CPAP with respect to its impact on ventilation distribution in healthy adults and CF subjects EIT might be used to individualise respiratory physiotherapy.http://europepmc.org/articles/PMC4164356?pdf=render |
| spellingShingle | Markus Wettstein Lorenz Radlinger Thomas Riedel Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis. PLoS ONE |
| title | Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis. |
| title_full | Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis. |
| title_fullStr | Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis. |
| title_full_unstemmed | Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis. |
| title_short | Effect of different breathing aids on ventilation distribution in adults with cystic fibrosis. |
| title_sort | effect of different breathing aids on ventilation distribution in adults with cystic fibrosis |
| url | http://europepmc.org/articles/PMC4164356?pdf=render |
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