Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study
Abstract Background Juvenile myoclonic epilepsy (JME) is the most common syndrome of idiopathic generalized epilepsy. Although resting-state functional magnetic resonance imaging (rs-fMRI) studies have found thalamocortical circuit dysfunction in patients with JME, the pathophysiological mechanism o...
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| Format: | Article |
| Language: | English |
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BMC
2022-08-01
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| Series: | Acta Epileptologica |
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| Online Access: | https://doi.org/10.1186/s42494-022-00101-4 |
| _version_ | 1818498895657828352 |
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| author | Linyuan Qin Yingying Zhang Jiechuan Ren Du Lei Xiuli Li Tianhua Yang Qiyong Gong Dong Zhou |
| author_facet | Linyuan Qin Yingying Zhang Jiechuan Ren Du Lei Xiuli Li Tianhua Yang Qiyong Gong Dong Zhou |
| author_sort | Linyuan Qin |
| collection | DOAJ |
| description | Abstract Background Juvenile myoclonic epilepsy (JME) is the most common syndrome of idiopathic generalized epilepsy. Although resting-state functional magnetic resonance imaging (rs-fMRI) studies have found thalamocortical circuit dysfunction in patients with JME, the pathophysiological mechanism of JME remains unclear. In this study, we used three complementary parameters of rs-fMRI to investigate aberrant brain activity in JME patients in comparison to that of healthy controls. Methods Rs-fMRI and clinical data were acquired from 49 patients with JME undergoing monotherapy and 44 age- and sex-matched healthy controls. After fMRI data preprocessing, the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC) were calculated and compared between the two groups. Correlation analysis was conducted to explore the relationship between local brain abnormalities and clinical features in JME patients. Results Compared with the controls, the JME patients exhibited significantly decreased fALFF, ReHo and DC in the cerebellum, inferior parietal lobe, and visual cortex (including the fusiform and the lingual and middle occipital gyri), and increased DC in the right orbitofrontal cortex. In the JME patients, there were no regions with reduced ReHo compared to the controls. No significant correlation was observed between regional abnormalities of fALFF, ReHo or DC, and clinical features. Conclusions We demonstrated a wide range of abnormal functional activity in the brains of patients with JME, including the prefrontal cortex, visual cortex, default mode network, and cerebellum. The results suggest dysfunctions of the cerebello-cerebral circuits, which provide a clue on the potential pathogenesis of JME. |
| first_indexed | 2024-12-10T20:21:48Z |
| format | Article |
| id | doaj.art-078374198a76496a81074ba10485f48c |
| institution | Directory Open Access Journal |
| issn | 2524-4434 |
| language | English |
| last_indexed | 2024-12-10T20:21:48Z |
| publishDate | 2022-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Acta Epileptologica |
| spelling | doaj.art-078374198a76496a81074ba10485f48c2022-12-22T01:35:00ZengBMCActa Epileptologica2524-44342022-08-01411810.1186/s42494-022-00101-4Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI studyLinyuan Qin0Yingying Zhang1Jiechuan Ren2Du Lei3Xiuli Li4Tianhua Yang5Qiyong Gong6Dong Zhou7Department of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan UniversityDepartment of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityDepartment of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan UniversityDepartment of Neurology, West China Hospital, Sichuan UniversityAbstract Background Juvenile myoclonic epilepsy (JME) is the most common syndrome of idiopathic generalized epilepsy. Although resting-state functional magnetic resonance imaging (rs-fMRI) studies have found thalamocortical circuit dysfunction in patients with JME, the pathophysiological mechanism of JME remains unclear. In this study, we used three complementary parameters of rs-fMRI to investigate aberrant brain activity in JME patients in comparison to that of healthy controls. Methods Rs-fMRI and clinical data were acquired from 49 patients with JME undergoing monotherapy and 44 age- and sex-matched healthy controls. After fMRI data preprocessing, the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and degree centrality (DC) were calculated and compared between the two groups. Correlation analysis was conducted to explore the relationship between local brain abnormalities and clinical features in JME patients. Results Compared with the controls, the JME patients exhibited significantly decreased fALFF, ReHo and DC in the cerebellum, inferior parietal lobe, and visual cortex (including the fusiform and the lingual and middle occipital gyri), and increased DC in the right orbitofrontal cortex. In the JME patients, there were no regions with reduced ReHo compared to the controls. No significant correlation was observed between regional abnormalities of fALFF, ReHo or DC, and clinical features. Conclusions We demonstrated a wide range of abnormal functional activity in the brains of patients with JME, including the prefrontal cortex, visual cortex, default mode network, and cerebellum. The results suggest dysfunctions of the cerebello-cerebral circuits, which provide a clue on the potential pathogenesis of JME.https://doi.org/10.1186/s42494-022-00101-4Juvenile myoclonic epilepsyResting-state functional magnetic resonance imagingFractional amplitude of low-frequency fluctuationRegional homogeneityDegree centrality |
| spellingShingle | Linyuan Qin Yingying Zhang Jiechuan Ren Du Lei Xiuli Li Tianhua Yang Qiyong Gong Dong Zhou Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study Acta Epileptologica Juvenile myoclonic epilepsy Resting-state functional magnetic resonance imaging Fractional amplitude of low-frequency fluctuation Regional homogeneity Degree centrality |
| title | Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study |
| title_full | Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study |
| title_fullStr | Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study |
| title_full_unstemmed | Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study |
| title_short | Altered brain activity in juvenile myoclonic epilepsy with a monotherapy: a resting-state fMRI study |
| title_sort | altered brain activity in juvenile myoclonic epilepsy with a monotherapy a resting state fmri study |
| topic | Juvenile myoclonic epilepsy Resting-state functional magnetic resonance imaging Fractional amplitude of low-frequency fluctuation Regional homogeneity Degree centrality |
| url | https://doi.org/10.1186/s42494-022-00101-4 |
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