Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice

Real-Time MRI Guidance for Reproducible Hyperosmolar Opening of the Blood-Brain Barrier in Mice

The blood-brain barrier (BBB) prevents effective delivery of most therapeutic agents to the brain. Intra-arterial (IA) infusion of hyperosmotic mannitol has been widely used to open the BBB and improve parenchymal targeting, but the extent of BBB disruption has varied widely with therapeutic outcome...

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Bibliographic Details
Main Authors: Chengyan Chu, Guanshu Liu, Miroslaw Janowski, Jeff W. M. Bulte, Shen Li, Monica Pearl, Piotr Walczak
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Neurology
Subjects:
blood brain barrier
intra-arterial
mannitol
MRI
mouse model
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2018.00921/full

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