Somatic mutation patterns and compound response in cancers
The use of various cancer cell lines can recapitulate knowntumor-associated mutations and genetically define cancersubsets. This approach also enables comparative surveys ofassociations between cancer mutations and drug responses.Here, we analyzed the effects of ∼40,000 compounds oncancer cell lines...
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2013-02-01
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| Series: | BMB Reports |
| Subjects: | |
| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI2MTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0yJTVEMTMwMjI2MTg0NF8lMjgwOTctMTAyJTI5Qk1CXzEyLTIyNi5wZGY= |
| _version_ | 1819082739505168384 |
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| author | Ningning He Nayoung Kim Sukjoon Yoon |
| author_facet | Ningning He Nayoung Kim Sukjoon Yoon |
| author_sort | Ningning He |
| collection | DOAJ |
| description | The use of various cancer cell lines can recapitulate knowntumor-associated mutations and genetically define cancersubsets. This approach also enables comparative surveys ofassociations between cancer mutations and drug responses.Here, we analyzed the effects of ∼40,000 compounds oncancer cell lines that showed diverse mutation-dependentsensitivity profiles. Over 1,000 compounds exhibited uniquesensitivity on cell lines with specific mutational genotypes,and these compounds were clustered into six different classesof mutation-oriented sensitivity. The present analysis providesnew insights into the relationship between somatic mutationsand selectivity response of chemicals, and these results shouldhave applications related to predicting and optimizing therapeuticwindows for anti-cancer agents. [BMB Reports 2013;46(2): 97-102] |
| first_indexed | 2024-12-21T20:21:28Z |
| format | Article |
| id | doaj.art-0785d987c42e4b15850ee557c47391e5 |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-12-21T20:21:28Z |
| publishDate | 2013-02-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-0785d987c42e4b15850ee557c47391e52022-12-21T18:51:28ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2013-02-0146297102http://dx.doi.org/10.5483/BMBRep.2013.46.2.226Somatic mutation patterns and compound response in cancersNingning HeNayoung KimSukjoon YoonThe use of various cancer cell lines can recapitulate knowntumor-associated mutations and genetically define cancersubsets. This approach also enables comparative surveys ofassociations between cancer mutations and drug responses.Here, we analyzed the effects of ∼40,000 compounds oncancer cell lines that showed diverse mutation-dependentsensitivity profiles. Over 1,000 compounds exhibited uniquesensitivity on cell lines with specific mutational genotypes,and these compounds were clustered into six different classesof mutation-oriented sensitivity. The present analysis providesnew insights into the relationship between somatic mutationsand selectivity response of chemicals, and these results shouldhave applications related to predicting and optimizing therapeuticwindows for anti-cancer agents. [BMB Reports 2013;46(2): 97-102]http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI2MTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0yJTVEMTMwMjI2MTg0NF8lMjgwOTctMTAyJTI5Qk1CXzEyLTIyNi5wZGY=Cancer mutationCell line enrichment analysisCompound responseGI50NCI60 |
| spellingShingle | Ningning He Nayoung Kim Sukjoon Yoon Somatic mutation patterns and compound response in cancers BMB Reports Cancer mutation Cell line enrichment analysis Compound response GI50 NCI60 |
| title | Somatic mutation patterns and compound response in cancers |
| title_full | Somatic mutation patterns and compound response in cancers |
| title_fullStr | Somatic mutation patterns and compound response in cancers |
| title_full_unstemmed | Somatic mutation patterns and compound response in cancers |
| title_short | Somatic mutation patterns and compound response in cancers |
| title_sort | somatic mutation patterns and compound response in cancers |
| topic | Cancer mutation Cell line enrichment analysis Compound response GI50 NCI60 |
| url | http://bmbreports.org/jbmb/pdf.php?data=MTMwOTI2MTdAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni0yJTVEMTMwMjI2MTg0NF8lMjgwOTctMTAyJTI5Qk1CXzEyLTIyNi5wZGY= |
| work_keys_str_mv | AT ningninghe somaticmutationpatternsandcompoundresponseincancers AT nayoungkim somaticmutationpatternsandcompoundresponseincancers AT sukjoonyoon somaticmutationpatternsandcompoundresponseincancers |