Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation
Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart di...
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| Format: | Article |
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Elsevier
2017-02-01
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| Series: | Japanese Dental Science Review |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1882761616300230 |
| _version_ | 1818962670756298752 |
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| author | Yosuke Yamawaki Kana Oue Satomi Shirawachi Satoshi Asano Kae Harada Takashi Kanematsu |
| author_facet | Yosuke Yamawaki Kana Oue Satomi Shirawachi Satoshi Asano Kae Harada Takashi Kanematsu |
| author_sort | Yosuke Yamawaki |
| collection | DOAJ |
| description | Obesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol. Prevention and control of obesity is complex, and requires a multifaceted approach. The elucidation of molecular mechanisms driving fat metabolism (adipogenesis and lipolysis) aims at developing clinical treatments to control obesity. We recently reported a new regulatory mechanism in fat metabolism: a protein phosphatase binding protein, phospholipase C-related catalytically inactive protein (PRIP), regulates lipolysis in white adipocytes and heat production in brown adipocytes via phosphoregulation. Deficiency of PRIP in mice led to reduced fat accumulation and increased energy expenditure, resulting in a lean phenotype. Here, we evaluate PRIP as a new therapeutic target for the control of obesity. |
| first_indexed | 2024-12-20T12:33:01Z |
| format | Article |
| id | doaj.art-0786c98eb9ad4fd691f512eab5a96ef7 |
| institution | Directory Open Access Journal |
| issn | 1882-7616 |
| language | English |
| last_indexed | 2024-12-20T12:33:01Z |
| publishDate | 2017-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Japanese Dental Science Review |
| spelling | doaj.art-0786c98eb9ad4fd691f512eab5a96ef72022-12-21T19:40:39ZengElsevierJapanese Dental Science Review1882-76162017-02-01531182410.1016/j.jdsr.2016.06.001Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammationYosuke Yamawaki0Kana Oue1Satomi Shirawachi2Satoshi Asano3Kae Harada4Takashi Kanematsu5Department of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanDepartment of Cellular and Molecular Pharmacology, Division of Basic Life Sciences, Institute of Biomedical and Health Sciences, Hiroshima University, Hiroshima 734-8553, JapanObesity is defined as abnormal or excessive fat accumulation. Chronic inflammation in fat influences the development of obesity-related diseases. Many reports state that obesity increases the risk of morbidity in many diseases, including hypertension, dyslipidemia, type 2 diabetes, coronary heart disease, stroke, sleep apnea, and breast, prostate and colon cancers, leading to increased mortality. Obesity is also associated with chronic neuropathologic conditions such as depression and Alzheimer's disease. However, there is strong evidence that weight loss reduces these risks, by limiting blood pressure and improving levels of serum triglycerides, total cholesterol, low-density lipoprotein (LDL)-cholesterol, and high-density lipoprotein (HDL)-cholesterol. Prevention and control of obesity is complex, and requires a multifaceted approach. The elucidation of molecular mechanisms driving fat metabolism (adipogenesis and lipolysis) aims at developing clinical treatments to control obesity. We recently reported a new regulatory mechanism in fat metabolism: a protein phosphatase binding protein, phospholipase C-related catalytically inactive protein (PRIP), regulates lipolysis in white adipocytes and heat production in brown adipocytes via phosphoregulation. Deficiency of PRIP in mice led to reduced fat accumulation and increased energy expenditure, resulting in a lean phenotype. Here, we evaluate PRIP as a new therapeutic target for the control of obesity.http://www.sciencedirect.com/science/article/pii/S1882761616300230Brown adipocyteEnergy expenditureInflammationLipolysisObesityWhite adipocyte |
| spellingShingle | Yosuke Yamawaki Kana Oue Satomi Shirawachi Satoshi Asano Kae Harada Takashi Kanematsu Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation Japanese Dental Science Review Brown adipocyte Energy expenditure Inflammation Lipolysis Obesity White adipocyte |
| title | Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation |
| title_full | Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation |
| title_fullStr | Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation |
| title_full_unstemmed | Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation |
| title_short | Phospholipase C-related catalytically inactive protein can regulate obesity, a state of peripheral inflammation |
| title_sort | phospholipase c related catalytically inactive protein can regulate obesity a state of peripheral inflammation |
| topic | Brown adipocyte Energy expenditure Inflammation Lipolysis Obesity White adipocyte |
| url | http://www.sciencedirect.com/science/article/pii/S1882761616300230 |
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