What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and Downregulation
Although registered since 2007, knowledge about changes in testosterone concentrations (T), testicular and prostatic volumes (TV, PV) and semen quality, as well as the time point of infertility following treatment with a 4.7 mg deslorelin (DES) slow-release implant, is limited. Therefore, seven sexu...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Animals |
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| Online Access: | https://www.mdpi.com/2076-2615/12/18/2379 |
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| author | Sabrina Stempel Hanna Körber Larena Reifarth Gerhard Schuler Sandra Goericke-Pesch |
| author_facet | Sabrina Stempel Hanna Körber Larena Reifarth Gerhard Schuler Sandra Goericke-Pesch |
| author_sort | Sabrina Stempel |
| collection | DOAJ |
| description | Although registered since 2007, knowledge about changes in testosterone concentrations (T), testicular and prostatic volumes (TV, PV) and semen quality, as well as the time point of infertility following treatment with a 4.7 mg deslorelin (DES) slow-release implant, is limited. Therefore, seven sexually mature male dogs were treated with DES (TG); three male dogs treated with saline served as controls (CG). The study assessed local tolerance, TV, PV, semen parameters and T subsequent to GnRH/hCG stimulation in regular intervals. Local tolerance was good. In TG, T was increased right after treatment, but decreased four hours afterwards. Subsequently, TV, PV, semen quality and T decreased over time in TG, but not CG. T was basal (≤0.1 ng/mL) from D28 onwards. Response to GnRH/hCG stimulation was variable, with two TG dogs having increased T post-stimulation on all study days independent of pre-treatment concentrations. A(zoo)spermia in TG was observed from D35–D77 in all seven dogs. Whereas treatment was still effective in six TG dogs five months after implant insertion, it was fully reversed in one dog in terms of T and spermatozoa on the last examination. These results indicate high variation in individual dogs, necessary to consider when advising dog owners. |
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| format | Article |
| id | doaj.art-0787938d548f4771a766cc6c29e4fb6a |
| institution | Directory Open Access Journal |
| issn | 2076-2615 |
| language | English |
| last_indexed | 2024-03-10T00:56:21Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
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| spelling | doaj.art-0787938d548f4771a766cc6c29e4fb6a2023-11-23T14:41:56ZengMDPI AGAnimals2076-26152022-09-011218237910.3390/ani12182379What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and DownregulationSabrina Stempel0Hanna Körber1Larena Reifarth2Gerhard Schuler3Sandra Goericke-Pesch4Reproductive Unit—Clinic for Small Animals, University of Veterinary Medicine Hanover, Foundation, 30559 Hannover, GermanyReproductive Unit—Clinic for Small Animals, University of Veterinary Medicine Hanover, Foundation, 30559 Hannover, GermanyReproductive Unit—Clinic for Small Animals, University of Veterinary Medicine Hanover, Foundation, 30559 Hannover, GermanyClinic for Obstetrics, Gynecology and Andrology of Large and Small Animals, Klinikum Veterinärmedizin, Justus-Liebig-University Giessen, 35392 Giessen, GermanyReproductive Unit—Clinic for Small Animals, University of Veterinary Medicine Hanover, Foundation, 30559 Hannover, GermanyAlthough registered since 2007, knowledge about changes in testosterone concentrations (T), testicular and prostatic volumes (TV, PV) and semen quality, as well as the time point of infertility following treatment with a 4.7 mg deslorelin (DES) slow-release implant, is limited. Therefore, seven sexually mature male dogs were treated with DES (TG); three male dogs treated with saline served as controls (CG). The study assessed local tolerance, TV, PV, semen parameters and T subsequent to GnRH/hCG stimulation in regular intervals. Local tolerance was good. In TG, T was increased right after treatment, but decreased four hours afterwards. Subsequently, TV, PV, semen quality and T decreased over time in TG, but not CG. T was basal (≤0.1 ng/mL) from D28 onwards. Response to GnRH/hCG stimulation was variable, with two TG dogs having increased T post-stimulation on all study days independent of pre-treatment concentrations. A(zoo)spermia in TG was observed from D35–D77 in all seven dogs. Whereas treatment was still effective in six TG dogs five months after implant insertion, it was fully reversed in one dog in terms of T and spermatozoa on the last examination. These results indicate high variation in individual dogs, necessary to consider when advising dog owners.https://www.mdpi.com/2076-2615/12/18/2379deslorelinGnRH stimulation testhCG stimulation testmale dogsflare up |
| spellingShingle | Sabrina Stempel Hanna Körber Larena Reifarth Gerhard Schuler Sandra Goericke-Pesch What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and Downregulation Animals deslorelin GnRH stimulation test hCG stimulation test male dogs flare up |
| title | What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and Downregulation |
| title_full | What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and Downregulation |
| title_fullStr | What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and Downregulation |
| title_full_unstemmed | What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and Downregulation |
| title_short | What Happens in Male Dogs after Treatment with a 4.7 mg Deslorelin Implant? I. Flare up and Downregulation |
| title_sort | what happens in male dogs after treatment with a 4 7 mg deslorelin implant i flare up and downregulation |
| topic | deslorelin GnRH stimulation test hCG stimulation test male dogs flare up |
| url | https://www.mdpi.com/2076-2615/12/18/2379 |
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