A hybrid in silico/in-cell controller for microbial bioprocesses with process-model mismatch
Abstract Bioprocess optimization using mathematical models is prevalent, yet the discrepancy between model predictions and actual processes, known as process-model mismatch (PMM), remains a significant challenge. This study proposes a novel hybrid control system called the hybrid in silico/in-cell c...
Main Authors: | Tomoki Ohkubo, Yuki Soma, Yuichi Sakumura, Taizo Hanai, Katsuyuki Kunida |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-09-01
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Series: | Scientific Reports |
Online Access: | https://doi.org/10.1038/s41598-023-40469-y |
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