A hybrid in silico/in-cell controller for microbial bioprocesses with process-model mismatch

Abstract Bioprocess optimization using mathematical models is prevalent, yet the discrepancy between model predictions and actual processes, known as process-model mismatch (PMM), remains a significant challenge. This study proposes a novel hybrid control system called the hybrid in silico/in-cell c...

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Bibliographic Details
Main Authors: Tomoki Ohkubo, Yuki Soma, Yuichi Sakumura, Taizo Hanai, Katsuyuki Kunida
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40469-y

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