Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation
Abstract Extremely low alanine aminotransferase (ALT) may reflect aging, frailty, sarcopenia, and malnutrition in several cardiovascular diseases, but the association between low ALT and patient characteristics, cardiovascular and all-cause mortality is not well investigated in the population with a...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16435-5 |
| _version_ | 1818517679500165120 |
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| author | Yuki Saito Yasuo Okumura Koichi Nagashima Daisuke Fukamachi Katsuaki Yokoyama Naoya Matsumoto Eizo Tachibana Keiichiro Kuronuma Koji Oiwa Michiaki Matsumoto Toshihiko Nishida Toshiaki Kojima Shoji Hanada Kazumiki Nomoto Kazumasa Sonoda Ken Arima Fumiyuki Takahashi Tomobumi Kotani Kimie Ohkubo Seiji Fukushima Satoru Itou Kunio Kondo Hideyuki Ando Yasumi Ohno Motoyuki Onikura Atsushi Hirayama |
| author_facet | Yuki Saito Yasuo Okumura Koichi Nagashima Daisuke Fukamachi Katsuaki Yokoyama Naoya Matsumoto Eizo Tachibana Keiichiro Kuronuma Koji Oiwa Michiaki Matsumoto Toshihiko Nishida Toshiaki Kojima Shoji Hanada Kazumiki Nomoto Kazumasa Sonoda Ken Arima Fumiyuki Takahashi Tomobumi Kotani Kimie Ohkubo Seiji Fukushima Satoru Itou Kunio Kondo Hideyuki Ando Yasumi Ohno Motoyuki Onikura Atsushi Hirayama |
| author_sort | Yuki Saito |
| collection | DOAJ |
| description | Abstract Extremely low alanine aminotransferase (ALT) may reflect aging, frailty, sarcopenia, and malnutrition in several cardiovascular diseases, but the association between low ALT and patient characteristics, cardiovascular and all-cause mortality is not well investigated in the population with atrial fibrillation. We conducted a post hoc analysis of a prospective, observational multicenter study. Patients with nonvalvular AF in the SAKURA AF Registry (n = 3156) were classified into 3 tertiles according to baseline ALT: first (ALT ≤ 15 U/L, n = 1098), second (15 < ALT < 23 U/L, n = 1055), and third (ALT ≥ 23 U/L, n = 1003). The first tertile had an older age; lower body mass index (BMI); higher prevalence of heart failure; and lower hemoglobin, total cholesterol, and triglycerides (all P < 0.05). During median 39.2 months follow-up, the first tertile had significantly higher incidences of cardiovascular and all-cause mortality (log-rank P < 0.001). Lower ALT was significantly associated with the incidence of cardiovascular and all-cause mortality, even after adjusting for clinically relevant factors (P < 0.05). Low ALT may reflect aging, sarcopenia, and malnutrition and be independently associated with a high risk of all-cause mortality in patients with AF. |
| first_indexed | 2024-12-11T00:59:32Z |
| format | Article |
| id | doaj.art-07886eedff26491cb5ede53cb2b8b575 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-11T00:59:32Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-07886eedff26491cb5ede53cb2b8b5752022-12-22T01:26:21ZengNature PortfolioScientific Reports2045-23222022-07-011211810.1038/s41598-022-16435-5Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillationYuki Saito0Yasuo Okumura1Koichi Nagashima2Daisuke Fukamachi3Katsuaki Yokoyama4Naoya Matsumoto5Eizo Tachibana6Keiichiro Kuronuma7Koji Oiwa8Michiaki Matsumoto9Toshihiko Nishida10Toshiaki Kojima11Shoji Hanada12Kazumiki Nomoto13Kazumasa Sonoda14Ken Arima15Fumiyuki Takahashi16Tomobumi Kotani17Kimie Ohkubo18Seiji Fukushima19Satoru Itou20Kunio Kondo21Hideyuki Ando22Yasumi Ohno23Motoyuki Onikura24Atsushi Hirayama25Division of Cardiology, Department of Medicine, Nihon University School of MedicineDivision of Cardiology, Department of Medicine, Nihon University School of MedicineDivision of Cardiology, Department of Medicine, Nihon University School of MedicineDivision of Cardiology, Department of Medicine, Nihon University School of MedicineDepartment of Cardiology, Nihon University HospitalDepartment of Cardiology, Nihon University HospitalKawaguchi Municipal Medical CenterKawaguchi Municipal Medical CenterYokohama Chuo HospitalYokohama Chuo HospitalYokohama Chuo HospitalSekishindo HospitalAsakadai Central General HospitalTokyo Rinkai HospitalTokyo Rinkai HospitalKasukabe Municipal HospitalYasuda HospitalMakita General HospitalItabashi Medical Association HospitalUkima Central HospitalItou Cardiovascular ClinicKondo ClinicKeiai ClinicOhno Medical ClinicOnikura ClinicDivision of Cardiology, Department of Medicine, Nihon University School of MedicineAbstract Extremely low alanine aminotransferase (ALT) may reflect aging, frailty, sarcopenia, and malnutrition in several cardiovascular diseases, but the association between low ALT and patient characteristics, cardiovascular and all-cause mortality is not well investigated in the population with atrial fibrillation. We conducted a post hoc analysis of a prospective, observational multicenter study. Patients with nonvalvular AF in the SAKURA AF Registry (n = 3156) were classified into 3 tertiles according to baseline ALT: first (ALT ≤ 15 U/L, n = 1098), second (15 < ALT < 23 U/L, n = 1055), and third (ALT ≥ 23 U/L, n = 1003). The first tertile had an older age; lower body mass index (BMI); higher prevalence of heart failure; and lower hemoglobin, total cholesterol, and triglycerides (all P < 0.05). During median 39.2 months follow-up, the first tertile had significantly higher incidences of cardiovascular and all-cause mortality (log-rank P < 0.001). Lower ALT was significantly associated with the incidence of cardiovascular and all-cause mortality, even after adjusting for clinically relevant factors (P < 0.05). Low ALT may reflect aging, sarcopenia, and malnutrition and be independently associated with a high risk of all-cause mortality in patients with AF.https://doi.org/10.1038/s41598-022-16435-5 |
| spellingShingle | Yuki Saito Yasuo Okumura Koichi Nagashima Daisuke Fukamachi Katsuaki Yokoyama Naoya Matsumoto Eizo Tachibana Keiichiro Kuronuma Koji Oiwa Michiaki Matsumoto Toshihiko Nishida Toshiaki Kojima Shoji Hanada Kazumiki Nomoto Kazumasa Sonoda Ken Arima Fumiyuki Takahashi Tomobumi Kotani Kimie Ohkubo Seiji Fukushima Satoru Itou Kunio Kondo Hideyuki Ando Yasumi Ohno Motoyuki Onikura Atsushi Hirayama Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation Scientific Reports |
| title | Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation |
| title_full | Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation |
| title_fullStr | Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation |
| title_full_unstemmed | Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation |
| title_short | Low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation |
| title_sort | low alanine aminotransferase levels are independently associated with mortality risk in patients with atrial fibrillation |
| url | https://doi.org/10.1038/s41598-022-16435-5 |
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