Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure
Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are mole...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-07-01
|
| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/12/14/2750 |
| _version_ | 1827731932392194048 |
|---|---|
| author | Lucas de Freitas Pedrosa Karen Rebouças Nascimento Caroline Giacomelli Soares Débora Preceliano de Oliveira Paul de Vos João Paulo Fabi |
| author_facet | Lucas de Freitas Pedrosa Karen Rebouças Nascimento Caroline Giacomelli Soares Débora Preceliano de Oliveira Paul de Vos João Paulo Fabi |
| author_sort | Lucas de Freitas Pedrosa |
| collection | DOAJ |
| description | Pectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. Cancer cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. One of the greater extents of recent pectin technological usage involves nanoencapsulation methods for many different compounds, ranging from chemotherapy and immunotherapy to natural extracts from fruits and other sources. Structural modification (modified pectin) is also utilized to enhance the use of dietary fiber. Although pectin is already recognized as a component of significant importance, there is still a need for a comprehensive review that delves into its intricate relationships with biological effects, which depend on the source and structure of pectin. This review covers all levels of clinical research, including cell culture, animal studies, and clinical trials, to understand how the plant source and pectin structures influence the biological effects in humans and some technological applications of pectin regarding human health. |
| first_indexed | 2024-03-11T00:42:37Z |
| format | Article |
| id | doaj.art-078973ca2b524b89a492bc0417607d7d |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T00:42:37Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-078973ca2b524b89a492bc0417607d7d2023-11-18T21:01:32ZengMDPI AGPlants2223-77472023-07-011214275010.3390/plants12142750Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical StructureLucas de Freitas Pedrosa0Karen Rebouças Nascimento1Caroline Giacomelli Soares2Débora Preceliano de Oliveira3Paul de Vos4João Paulo Fabi5Department of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, BrazilDepartment of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, BrazilDepartment of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, BrazilDepartment of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, BrazilDepartment of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, 9713 GZ Groningen, The NetherlandsDepartment of Food Science and Experimental Nutrition, School of Pharmaceutical Sciences, University of São Paulo, São Paulo 05508-000, SP, BrazilPectin, a plant-derived polysaccharide, possesses immense technological and biological application value. Several variables influence pectin’s physicochemical aspects, resulting in different fermentations, interactions with receptors, and other functional properties. Some of those variables are molecular weight, degree of methylation and blockiness, and monosaccharide composition. Cancer cell cytotoxicity, important fermentation-related byproducts, immunomodulation, and technological application were found in cell culture, animal models, and preclinical and clinical assessments. One of the greater extents of recent pectin technological usage involves nanoencapsulation methods for many different compounds, ranging from chemotherapy and immunotherapy to natural extracts from fruits and other sources. Structural modification (modified pectin) is also utilized to enhance the use of dietary fiber. Although pectin is already recognized as a component of significant importance, there is still a need for a comprehensive review that delves into its intricate relationships with biological effects, which depend on the source and structure of pectin. This review covers all levels of clinical research, including cell culture, animal studies, and clinical trials, to understand how the plant source and pectin structures influence the biological effects in humans and some technological applications of pectin regarding human health.https://www.mdpi.com/2223-7747/12/14/2750pectinfunctional propertiesfermentationhuman healthdietary fibertechnological application |
| spellingShingle | Lucas de Freitas Pedrosa Karen Rebouças Nascimento Caroline Giacomelli Soares Débora Preceliano de Oliveira Paul de Vos João Paulo Fabi Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure Plants pectin functional properties fermentation human health dietary fiber technological application |
| title | Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure |
| title_full | Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure |
| title_fullStr | Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure |
| title_full_unstemmed | Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure |
| title_short | Unveiling Plant-Based Pectins: Exploring the Interplay of Direct Effects, Fermentation, and Technological Applications in Clinical Research with a Focus on the Chemical Structure |
| title_sort | unveiling plant based pectins exploring the interplay of direct effects fermentation and technological applications in clinical research with a focus on the chemical structure |
| topic | pectin functional properties fermentation human health dietary fiber technological application |
| url | https://www.mdpi.com/2223-7747/12/14/2750 |
| work_keys_str_mv | AT lucasdefreitaspedrosa unveilingplantbasedpectinsexploringtheinterplayofdirecteffectsfermentationandtechnologicalapplicationsinclinicalresearchwithafocusonthechemicalstructure AT karenreboucasnascimento unveilingplantbasedpectinsexploringtheinterplayofdirecteffectsfermentationandtechnologicalapplicationsinclinicalresearchwithafocusonthechemicalstructure AT carolinegiacomellisoares unveilingplantbasedpectinsexploringtheinterplayofdirecteffectsfermentationandtechnologicalapplicationsinclinicalresearchwithafocusonthechemicalstructure AT deboraprecelianodeoliveira unveilingplantbasedpectinsexploringtheinterplayofdirecteffectsfermentationandtechnologicalapplicationsinclinicalresearchwithafocusonthechemicalstructure AT pauldevos unveilingplantbasedpectinsexploringtheinterplayofdirecteffectsfermentationandtechnologicalapplicationsinclinicalresearchwithafocusonthechemicalstructure AT joaopaulofabi unveilingplantbasedpectinsexploringtheinterplayofdirecteffectsfermentationandtechnologicalapplicationsinclinicalresearchwithafocusonthechemicalstructure |