Recombinant Uncarboxylated Osteocalcin Per Se Enhances Mouse Skeletal Muscle Glucose Uptake in both Extensor Digitorum Longus and Soleus Muscles

Recombinant Uncarboxylated Osteocalcin Per Se Enhances Mouse Skeletal Muscle Glucose Uptake in both Extensor Digitorum Longus and Soleus Muscles

Emerging evidence suggests that undercarboxylated osteocalcin (ucOC) improves muscle glucose uptake in rodents. However, whether ucOC can directly increase glucose uptake in both glycolytic and oxidative muscles and the possible mechanisms of action still need further exploration. We tested the hypo...

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Bibliographic Details
Main Authors: Xuzhu Lin, Lewan Parker, Emma Mclennan, Xinmei Zhang, Alan Hayes, Glenn McConell, Tara C. Brennan-Speranza, Itamar Levinger
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-11-01
Series:Frontiers in Endocrinology
Subjects:
undercarboxylated osteocalcin
skeletal muscle
glucose uptake
extracellular signal-regulated kinase
adenosine monophosphate-activated protein kinase
mechanistic target of rapamycin complex 2-AKT-AS160 signaling cascade
Online Access:http://journal.frontiersin.org/article/10.3389/fendo.2017.00330/full

Internet

http://journal.frontiersin.org/article/10.3389/fendo.2017.00330/full

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