Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS

Abstract The fatal motor neuron (MN) disease Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive MN degeneration. Phrenic MNs (phMNs) controlling the activity of the diaphragm are prone to degeneration in ALS, leading to death by respiratory failure. Understanding of the mechanisms o...

Full description

Bibliographic Details
Main Authors: Louise Thiry, Julien Sirois, Thomas M. Durcan, Stefano Stifani
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-05925-z

Similar Items

Similar Items