Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study
Abstract Background High-flow nasal cannula (HFNC) oxygen therapy is essentially a constant-flow, noninvasive respiratory support system similar to a noninvasive ventilator operating in constant-flow mode. The clinical outcome of HFNC oxygen therapy is strongly associated with the pressure generated...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | BMC Pulmonary Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12890-023-02752-6 |
| _version_ | 1797453992738947072 |
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| author | Enqi Zhao Yilong Zhou Chunwei He Dedong Ma |
| author_facet | Enqi Zhao Yilong Zhou Chunwei He Dedong Ma |
| author_sort | Enqi Zhao |
| collection | DOAJ |
| description | Abstract Background High-flow nasal cannula (HFNC) oxygen therapy is essentially a constant-flow, noninvasive respiratory support system similar to a noninvasive ventilator operating in constant-flow mode. The clinical outcome of HFNC oxygen therapy is strongly associated with the pressure generated by high-flow gas and the patient’s comfort level. This study was performed to explore the relevant factors affecting pressure and comfort of HFNC oxygen therapy in vivo. Methods Thirty-five healthy volunteers were enrolled in the trial. They underwent placement of nasal cannulas of various inner diameters (3, 4 or 5 mm) and treatment with different HFNC devices [HFT-300 (Weishengkang Medical Technology Co., Ltd., Jiangsu China) or H-80 M (BMC Medical Co., Ltd., Beijing China)],and the nasal airway pressure and comfort were assessed. Multiple linear regression was used to determine predictors of airway pressure. Results Multiple linear regression showed that the end-expiratory pressure was associated with the flow rate, sex, height, and cannula size. The end-expiratory pressure increased by 0.6 cmH2O per 1-mm increase in cannula diameter, decreased by 0.3 cmH2O per 10-cm increase in participant height (with a 0.35 cmH2O decrease for men), and increased by 1 cmH2O when the flow rate increased by 10 L/min (R2 = 0.75, P < 0.05 for all variables in model). In addition, the pressure generated by the H-80 M device was higher than that generated by the HFT-300 device (P < 0.05). Discomfort manifested as difficulty in expiration, and its severity increased as the cannula diameter increased; however there was no significant difference in comfort between the two HFNC devices (P > 0.05). Conclusion In volunteers undergoing HFNC oxygen therapy, the nasal cannula diameter, flow rate, sex, height, and device model can affect the nasal airway pressure, and the nasal catheter diameter and flow rate can affect comfort. These factors should be given close attention in clinical practice. Trial registration ChiCTR2300068313 (date of first registration: 14 February 2023, https://www.chictr.org.cn ). |
| first_indexed | 2024-03-09T15:30:49Z |
| format | Article |
| id | doaj.art-078e2f6085f144088e3f41ccf54bdc65 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-09T15:30:49Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-078e2f6085f144088e3f41ccf54bdc652023-11-26T12:13:15ZengBMCBMC Pulmonary Medicine1471-24662023-11-0123111010.1186/s12890-023-02752-6Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer studyEnqi Zhao0Yilong Zhou1Chunwei He2Dedong Ma3Qilu Hospital of Shandong UniversityQilu Hospital of Shandong UniversityQilu Hospital of Shandong UniversityDepartment of Respiratory and Critical Care Medicine, Qilu Hospital of Shandong UniversityAbstract Background High-flow nasal cannula (HFNC) oxygen therapy is essentially a constant-flow, noninvasive respiratory support system similar to a noninvasive ventilator operating in constant-flow mode. The clinical outcome of HFNC oxygen therapy is strongly associated with the pressure generated by high-flow gas and the patient’s comfort level. This study was performed to explore the relevant factors affecting pressure and comfort of HFNC oxygen therapy in vivo. Methods Thirty-five healthy volunteers were enrolled in the trial. They underwent placement of nasal cannulas of various inner diameters (3, 4 or 5 mm) and treatment with different HFNC devices [HFT-300 (Weishengkang Medical Technology Co., Ltd., Jiangsu China) or H-80 M (BMC Medical Co., Ltd., Beijing China)],and the nasal airway pressure and comfort were assessed. Multiple linear regression was used to determine predictors of airway pressure. Results Multiple linear regression showed that the end-expiratory pressure was associated with the flow rate, sex, height, and cannula size. The end-expiratory pressure increased by 0.6 cmH2O per 1-mm increase in cannula diameter, decreased by 0.3 cmH2O per 10-cm increase in participant height (with a 0.35 cmH2O decrease for men), and increased by 1 cmH2O when the flow rate increased by 10 L/min (R2 = 0.75, P < 0.05 for all variables in model). In addition, the pressure generated by the H-80 M device was higher than that generated by the HFT-300 device (P < 0.05). Discomfort manifested as difficulty in expiration, and its severity increased as the cannula diameter increased; however there was no significant difference in comfort between the two HFNC devices (P > 0.05). Conclusion In volunteers undergoing HFNC oxygen therapy, the nasal cannula diameter, flow rate, sex, height, and device model can affect the nasal airway pressure, and the nasal catheter diameter and flow rate can affect comfort. These factors should be given close attention in clinical practice. Trial registration ChiCTR2300068313 (date of first registration: 14 February 2023, https://www.chictr.org.cn ).https://doi.org/10.1186/s12890-023-02752-6End-expiratory pressureComfortInfluencing factorHigh-flow nasal cannula |
| spellingShingle | Enqi Zhao Yilong Zhou Chunwei He Dedong Ma Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study BMC Pulmonary Medicine End-expiratory pressure Comfort Influencing factor High-flow nasal cannula |
| title | Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study |
| title_full | Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study |
| title_fullStr | Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study |
| title_full_unstemmed | Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study |
| title_short | Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study |
| title_sort | factors influencing nasal airway pressure and comfort in high flow nasal cannula oxygen therapy a volunteer study |
| topic | End-expiratory pressure Comfort Influencing factor High-flow nasal cannula |
| url | https://doi.org/10.1186/s12890-023-02752-6 |
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