A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

A Cas-BCAR3 co-regulatory circuit controls lamellipodia dynamics

Integrin adhesion complexes regulate cytoskeletal dynamics during cell migration. Adhesion activates phosphorylation of integrin-associated signaling proteins, including Cas (p130Cas, BCAR1), by Src-family kinases. Cas regulates leading-edge protrusion and migration in cooperation with its binding p...

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Bibliographic Details
Main Authors:	Elizabeth M Steenkiste, Jason D Berndt, Carissa Pilling, Christopher Simpkins, Jonathan A Cooper
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2021-06-01
Series:	eLife
Subjects:	phosphorylation ubiquitination phosphotyrosine cell migration
Online Access:	https://elifesciences.org/articles/67078

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