Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes
<p>Abstract</p> <p>Background</p> <p>The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common a...
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| Format: | Article |
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BMC
2012-06-01
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| Series: | BMC Research Notes |
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| Online Access: | http://www.biomedcentral.com/1756-0500/5/299 |
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| author | Voukeng Igor K Kuete Victor Dzoyem Jean P Fankam Aimé G Noumedem Jaures A K Kuiate Jules R Pages Jean-Marie |
| author_facet | Voukeng Igor K Kuete Victor Dzoyem Jean P Fankam Aimé G Noumedem Jaures A K Kuiate Jules R Pages Jean-Marie |
| author_sort | Voukeng Igor K |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.</p> <p>Results</p> <p>The extract of <it>Cinnamomum zeylanicum</it> against <it>Escherichia coli</it> ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of <it>Dorstenia psilurus</it> was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine<it>-β-</it> Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY).</p> <p>Conclusion</p> <p>The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.</p> |
| first_indexed | 2024-12-22T05:33:18Z |
| format | Article |
| id | doaj.art-0793270cc5764bedb25bbec327d937cf |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-22T05:33:18Z |
| publishDate | 2012-06-01 |
| publisher | BMC |
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| series | BMC Research Notes |
| spelling | doaj.art-0793270cc5764bedb25bbec327d937cf2022-12-21T18:37:23ZengBMCBMC Research Notes1756-05002012-06-015129910.1186/1756-0500-5-299Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypesVoukeng Igor KKuete VictorDzoyem Jean PFankam Aimé GNoumedem Jaures A KKuiate Jules RPages Jean-Marie<p>Abstract</p> <p>Background</p> <p>The present work was designed to evaluate the antibacterial properties of the methanol extracts of eleven selected Cameroonian spices on multi-drug resistant bacteria (MDR), and their ability to potentiate the effect of some common antibiotics used in therapy.</p> <p>Results</p> <p>The extract of <it>Cinnamomum zeylanicum</it> against <it>Escherichia coli</it> ATCC 8739 and AG100 strains showed the best activities, with the lowest minimal inhibitory concentration (MIC) of 64 μg/ml. The extract of <it>Dorstenia psilurus</it> was the most active when tested in the presence of an efflux pump inhibitor, phenylalanine Arginine<it>-β-</it> Naphtylamide (PAβN), a synergistic effect being observed in 56.25 % of the tested bacteria when it was combined with Erythromycin (ERY).</p> <p>Conclusion</p> <p>The present work evidently provides information on the role of some Cameroonian spices in the fight against multi-resistant bacteria.</p>http://www.biomedcentral.com/1756-0500/5/299Multi-Drug Resistant bacteriaSpicesMethanol extractCameroon |
| spellingShingle | Voukeng Igor K Kuete Victor Dzoyem Jean P Fankam Aimé G Noumedem Jaures A K Kuiate Jules R Pages Jean-Marie Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes BMC Research Notes Multi-Drug Resistant bacteria Spices Methanol extract Cameroon |
| title | Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes |
| title_full | Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes |
| title_fullStr | Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes |
| title_full_unstemmed | Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes |
| title_short | Antibacterial and antibiotic-potentiation activities of the methanol extract of some cameroonian spices against Gram-negative multi-drug resistant phenotypes |
| title_sort | antibacterial and antibiotic potentiation activities of the methanol extract of some cameroonian spices against gram negative multi drug resistant phenotypes |
| topic | Multi-Drug Resistant bacteria Spices Methanol extract Cameroon |
| url | http://www.biomedcentral.com/1756-0500/5/299 |
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