The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype
Objective:A functional polymorphism on the 16th exon of the alpha-actinin-3 gene has an effect on the protein structure and cellular signaling and therefore on muscle contraction. In this study, we aimed to analyze the alpha-actinin-3 rs1815739 polymorphism in 3-dimensional malocclusions and differe...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-06-01
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| Series: | Turkish Journal of Orthodontics |
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http://www.turkjorthod.org/archives/archive-detail/article-preview/the-association-of-actn3-rs1815739-polymorphism-wi/53285
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| author | Hussain Nihad Izaddin Alalim Başak Funda Eken Korkut Ulucan Fulya Özdemir |
| author_facet | Hussain Nihad Izaddin Alalim Başak Funda Eken Korkut Ulucan Fulya Özdemir |
| author_sort | Hussain Nihad Izaddin Alalim |
| collection | DOAJ |
| description | Objective:A functional polymorphism on the 16th exon of the alpha-actinin-3 gene has an effect on the protein structure and cellular signaling and therefore on muscle contraction. In this study, we aimed to analyze the alpha-actinin-3 rs1815739 polymorphism in 3-dimensional malocclusions and different craniofacial skeletal patterns.Methods: Forty-nine volunteering subjects enrolled for the study. Genotyping of alpha-actinin-3 rs1815739 polymorphism was performed using real-time polymerase chain reaction. Pre-orthodontic cephalometric radiographs were traced using NemoTech cephalometric tracing software. IBM SPSS Statistics for Windows was utilized to carry out statistical analysis. P < .05 was considered to be statistically significant.Results: The respective numbers and the percentages of alpha-actinin-3 rs1815739 polymorphisms for RR, RX, and XX genotypes were 39 (79.6%), 4 (8.2%), and 6 (12.2%), respectively. Twenty-one patients had low angle vertical patterns and 17 patients had Class I and the same number of the patients had Class III facial patterns. But none of these had statistically significant difference in terms of alpha-actinin-3 rs1815739 polymorphism and in vertical or sagittal facial patterns, and mandibular incisor inclination. When we examined the maxillary anteroposterior position, we found a significant difference between rs1815739 polymorphisms (P < .05). Also, we detected a significant difference between rs1815739 polymorphism and maxillary incisor inclination (P < .05).Conclusion: Maxillary incisor inclination and maxillary anteroposterior position are associated with alpha-actinin-3 rs1815739 polymorphism in a Turkish cohort. |
| first_indexed | 2024-03-12T20:39:56Z |
| format | Article |
| id | doaj.art-0793ead260ae40e894c5d6b4e2c3f6eb |
| institution | Directory Open Access Journal |
| issn | 2528-9659 2148-9505 |
| language | English |
| last_indexed | 2024-03-12T20:39:56Z |
| publishDate | 2022-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Turkish Journal of Orthodontics |
| spelling | doaj.art-0793ead260ae40e894c5d6b4e2c3f6eb2023-08-01T11:02:32ZengGalenos YayineviTurkish Journal of Orthodontics2528-96592148-95052022-06-0135212713210.5152/TurkJOrthod.2022.2117113049054The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion PhenotypeHussain Nihad Izaddin Alalim0Başak Funda Eken1Korkut Ulucan2Fulya Özdemir3 Department of Orthodontics, Marmara University, Faculty of Dentistry, İstanbul, Turkey Department of Medical Biology and Genetics, Marmara University, Faculty of Dentistry, İstanbul, Turkey Department of Medical Biology and Genetics, Marmara University, Faculty of Dentistry, İstanbul, Turkey Department of Orthodontics, Marmara University, Faculty of Dentistry, İstanbul, Turkey Objective:A functional polymorphism on the 16th exon of the alpha-actinin-3 gene has an effect on the protein structure and cellular signaling and therefore on muscle contraction. In this study, we aimed to analyze the alpha-actinin-3 rs1815739 polymorphism in 3-dimensional malocclusions and different craniofacial skeletal patterns.Methods: Forty-nine volunteering subjects enrolled for the study. Genotyping of alpha-actinin-3 rs1815739 polymorphism was performed using real-time polymerase chain reaction. Pre-orthodontic cephalometric radiographs were traced using NemoTech cephalometric tracing software. IBM SPSS Statistics for Windows was utilized to carry out statistical analysis. P < .05 was considered to be statistically significant.Results: The respective numbers and the percentages of alpha-actinin-3 rs1815739 polymorphisms for RR, RX, and XX genotypes were 39 (79.6%), 4 (8.2%), and 6 (12.2%), respectively. Twenty-one patients had low angle vertical patterns and 17 patients had Class I and the same number of the patients had Class III facial patterns. But none of these had statistically significant difference in terms of alpha-actinin-3 rs1815739 polymorphism and in vertical or sagittal facial patterns, and mandibular incisor inclination. When we examined the maxillary anteroposterior position, we found a significant difference between rs1815739 polymorphisms (P < .05). Also, we detected a significant difference between rs1815739 polymorphism and maxillary incisor inclination (P < .05).Conclusion: Maxillary incisor inclination and maxillary anteroposterior position are associated with alpha-actinin-3 rs1815739 polymorphism in a Turkish cohort. http://www.turkjorthod.org/archives/archive-detail/article-preview/the-association-of-actn3-rs1815739-polymorphism-wi/53285 actn3facial patternmalocclusionpolymorphism |
| spellingShingle | Hussain Nihad Izaddin Alalim Başak Funda Eken Korkut Ulucan Fulya Özdemir The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype Turkish Journal of Orthodontics actn3 facial pattern malocclusion polymorphism |
| title | The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype |
| title_full | The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype |
| title_fullStr | The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype |
| title_full_unstemmed | The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype |
| title_short | The Association of ACTN3 Rs1815739 Polymorphism with Various Malocclusion Phenotype |
| title_sort | association of actn3 rs1815739 polymorphism with various malocclusion phenotype |
| topic | actn3 facial pattern malocclusion polymorphism |
| url |
http://www.turkjorthod.org/archives/archive-detail/article-preview/the-association-of-actn3-rs1815739-polymorphism-wi/53285
|
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