Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil
Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microce...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-12-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/13/1/1 |
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| author | Andréia Veras Gonçalves Demócrito de B. Miranda-Filho Líbia Cristina Rocha Vilela Regina Coeli Ferreira Ramos Thalia V. B. de Araújo Rômulo A. L. de Vasconcelos Maria Angela Wanderley Rocha Sophie Helena Eickmann Marli Tenório Cordeiro Liana O. Ventura Ulisses Ramos Montarroyos Alessandra Mertens Brainer Maria Durce Costa Gomes Paula Fabiana Sobral da Silva Celina M. T. Martelli Elizabeth B. Brickley Ricardo A. A. Ximenes |
| author_facet | Andréia Veras Gonçalves Demócrito de B. Miranda-Filho Líbia Cristina Rocha Vilela Regina Coeli Ferreira Ramos Thalia V. B. de Araújo Rômulo A. L. de Vasconcelos Maria Angela Wanderley Rocha Sophie Helena Eickmann Marli Tenório Cordeiro Liana O. Ventura Ulisses Ramos Montarroyos Alessandra Mertens Brainer Maria Durce Costa Gomes Paula Fabiana Sobral da Silva Celina M. T. Martelli Elizabeth B. Brickley Ricardo A. A. Ximenes |
| author_sort | Andréia Veras Gonçalves |
| collection | DOAJ |
| description | Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6/21) and corpus callosum hypoplasia (20/21). Seizure crises were reported in 86% of the children. The most common—and clinically important—endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary. |
| first_indexed | 2024-04-11T09:44:54Z |
| format | Article |
| id | doaj.art-07948a8e4ac846a582c28841be21e921 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-11T09:44:54Z |
| publishDate | 2020-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-07948a8e4ac846a582c28841be21e9212022-12-22T04:31:02ZengMDPI AGViruses1999-49152020-12-01131110.3390/v13010001Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, BrazilAndréia Veras Gonçalves0Demócrito de B. Miranda-Filho1Líbia Cristina Rocha Vilela2Regina Coeli Ferreira Ramos3Thalia V. B. de Araújo4Rômulo A. L. de Vasconcelos5Maria Angela Wanderley Rocha6Sophie Helena Eickmann7Marli Tenório Cordeiro8Liana O. Ventura9Ulisses Ramos Montarroyos10Alessandra Mertens Brainer11Maria Durce Costa Gomes12Paula Fabiana Sobral da Silva13Celina M. T. Martelli14Elizabeth B. Brickley15Ricardo A. A. Ximenes16Department of Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, BrazilPostgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, BrazilDepartment of Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, BrazilDepartment Pediatric Infectious Disease, Oswaldo Cruz University Hospital, Recife 50100-130, BrazilDepartment of Social Medicine, Federal University of Pernambuco, Recife 50670-901, BrazilPostgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, BrazilDepartment Pediatric Infectious Disease, Oswaldo Cruz University Hospital, Recife 50100-130, BrazilMaternal and Child Department, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, BrazilUnit of Oswaldo Cruz Foundation (Fiocruz), Research Center Aggeu Magalhães (CPqAM), Recife 50670-420, BrazilDepartment of Ophthalmology, Altino Ventura Foundation, Recife 52171-011, BrazilPostgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, BrazilPostgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, BrazilPostgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, BrazilPostgraduation in Health Sciences, University of Pernambuco, Recife 50100-010, BrazilUnit of Oswaldo Cruz Foundation (Fiocruz), Research Center Aggeu Magalhães (CPqAM), Recife 50670-420, BrazilDepartment of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UKDepartment of Tropical Medicine, Health Sciences Center, Federal University of Pernambuco, Recife 50670-901, BrazilCongenital viral infections and the occurrence of septo-optic dysplasia, which is a combination of optic nerve hypoplasia, abnormal formation of structures along the midline of the brain, and pituitary hypofunction, support the biological plausibility of endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained the presence and describe endocrine dysfunction in 30 children with severe Zika-related microcephaly from the MERG Pediatric Cohort, referred for endocrinological evaluation between February and August 2019. Of the 30 children, 97% had severe microcephaly. The average age at the endocrinological consultation was 41 months and 53% were female. The most frequently observed endocrine dysfunctions comprised short stature, hypothyroidism, obesity and variants early puberty. These dysfunctions occurred alone 57% or in combination 43%. We found optic nerve hypoplasia (6/21) and corpus callosum hypoplasia (20/21). Seizure crises were reported in 86% of the children. The most common—and clinically important—endocrine dysfunctions were pubertal dysfunctions, thyroid disease, growth impairment, and obesity. These dysfunctions require careful monitoring and signal the need for endocrinological evaluation in children with Zika-related microcephaly, in order to make early diagnoses and implement appropriate treatment when necessary.https://www.mdpi.com/1999-4915/13/1/1microcephalyZikaobesityhypothyroidismpuberty |
| spellingShingle | Andréia Veras Gonçalves Demócrito de B. Miranda-Filho Líbia Cristina Rocha Vilela Regina Coeli Ferreira Ramos Thalia V. B. de Araújo Rômulo A. L. de Vasconcelos Maria Angela Wanderley Rocha Sophie Helena Eickmann Marli Tenório Cordeiro Liana O. Ventura Ulisses Ramos Montarroyos Alessandra Mertens Brainer Maria Durce Costa Gomes Paula Fabiana Sobral da Silva Celina M. T. Martelli Elizabeth B. Brickley Ricardo A. A. Ximenes Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil Viruses microcephaly Zika obesity hypothyroidism puberty |
| title | Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_full | Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_fullStr | Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_full_unstemmed | Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_short | Endocrine Dysfunction in Children with Zika-Related Microcephaly Who Were Born during the 2015 Epidemic in the State of Pernambuco, Brazil |
| title_sort | endocrine dysfunction in children with zika related microcephaly who were born during the 2015 epidemic in the state of pernambuco brazil |
| topic | microcephaly Zika obesity hypothyroidism puberty |
| url | https://www.mdpi.com/1999-4915/13/1/1 |
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