Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four AncestriesSummary

Assessing the Impact of PCSK9 and HMGCR Inhibition on Liver Function: Drug-Target Mendelian Randomization Analyses in Four AncestriesSummary

Background & Aims: Observational studies have linked lipid-lowering drug targets pro-protein convertase subtilisin/kexin 9 (PCSK9) and HMG-CoA reductase (HMGCR) with adverse liver outcomes; however, liver disease incidence varies across diverse populations, and the long-term hepatic impact o...

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Bibliographic Details
Main Authors: Daniel B. Rosoff, Andrew S. Bell, Josephin Wagner, Lucas A. Mavromatis, Ali Hamandi, Lauren Park, Jeesun Jung, Falk W. Lohoff
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
PCSK9
Statins
Drug-Target Mendelian Randomization
Hepatotoxicity
URM/URIM
Bias
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X23001637

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http://www.sciencedirect.com/science/article/pii/S2352345X23001637

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