Role of olmesartan in combination therapy in blood pressure control and vascular function
Carlos M Ferrario, Ronald D SmithWake Forest University School of Medicine, Winston-Salem, North Carolina, USAAbstract: Angiotensin receptor blockers have emerged as a first-line therapy in the management of hypertension and hypertension-related comorbidities. Since national and international guidel...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2010-08-01
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| Series: | Vascular Health and Risk Management |
| Online Access: | http://www.dovepress.com/role-of-olmesartan-in-combination-therapy-in-blood-pressure-control-an-a4994 |
| _version_ | 1811251972909563904 |
|---|---|
| author | Carlos M Ferrario Ronald D Smith |
| author_facet | Carlos M Ferrario Ronald D Smith |
| author_sort | Carlos M Ferrario |
| collection | DOAJ |
| description | Carlos M Ferrario, Ronald D SmithWake Forest University School of Medicine, Winston-Salem, North Carolina, USAAbstract: Angiotensin receptor blockers have emerged as a first-line therapy in the management of hypertension and hypertension-related comorbidities. Since national and international guidelines have stressed the need to control blood pressure to <140/90 mmHg in uncomplicated hypertension and <130/80 mmHg in those with associated comorbidities such as diabetes or chronic kidney disease, these goal blood pressures can only be achieved through combination therapy. Of several drugs that can be effectively combined to attain the recommended blood pressure goals, fixed-dose combinations of angiotensin receptor blockers and the calcium channel blocker amlodipine provide additive antihypertensive effects associated with a safe profile and increased adherence to therapy. In this article, we review the evidence regarding the beneficial effects of renin–angiotensin system blockade with olmesartan medoxomil and amlodipine in terms of blood pressure control and improvement of vascular function and target organ damage.Keywords: amlodipine, angiotensin receptor blockers, angiotensin-converting enzyme 2, hypertension, renin–angiotensin system |
| first_indexed | 2024-04-12T16:27:59Z |
| format | Article |
| id | doaj.art-07984ff6206b47e3b2420c261a792972 |
| institution | Directory Open Access Journal |
| issn | 1176-6344 1178-2048 |
| language | English |
| last_indexed | 2024-04-12T16:27:59Z |
| publishDate | 2010-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Vascular Health and Risk Management |
| spelling | doaj.art-07984ff6206b47e3b2420c261a7929722022-12-22T03:25:18ZengDove Medical PressVascular Health and Risk Management1176-63441178-20482010-08-012010default701709Role of olmesartan in combination therapy in blood pressure control and vascular functionCarlos M FerrarioRonald D SmithCarlos M Ferrario, Ronald D SmithWake Forest University School of Medicine, Winston-Salem, North Carolina, USAAbstract: Angiotensin receptor blockers have emerged as a first-line therapy in the management of hypertension and hypertension-related comorbidities. Since national and international guidelines have stressed the need to control blood pressure to <140/90 mmHg in uncomplicated hypertension and <130/80 mmHg in those with associated comorbidities such as diabetes or chronic kidney disease, these goal blood pressures can only be achieved through combination therapy. Of several drugs that can be effectively combined to attain the recommended blood pressure goals, fixed-dose combinations of angiotensin receptor blockers and the calcium channel blocker amlodipine provide additive antihypertensive effects associated with a safe profile and increased adherence to therapy. In this article, we review the evidence regarding the beneficial effects of renin–angiotensin system blockade with olmesartan medoxomil and amlodipine in terms of blood pressure control and improvement of vascular function and target organ damage.Keywords: amlodipine, angiotensin receptor blockers, angiotensin-converting enzyme 2, hypertension, renin–angiotensin systemhttp://www.dovepress.com/role-of-olmesartan-in-combination-therapy-in-blood-pressure-control-an-a4994 |
| spellingShingle | Carlos M Ferrario Ronald D Smith Role of olmesartan in combination therapy in blood pressure control and vascular function Vascular Health and Risk Management |
| title | Role of olmesartan in combination therapy in blood pressure control and vascular function |
| title_full | Role of olmesartan in combination therapy in blood pressure control and vascular function |
| title_fullStr | Role of olmesartan in combination therapy in blood pressure control and vascular function |
| title_full_unstemmed | Role of olmesartan in combination therapy in blood pressure control and vascular function |
| title_short | Role of olmesartan in combination therapy in blood pressure control and vascular function |
| title_sort | role of olmesartan in combination therapy in blood pressure control and vascular function |
| url | http://www.dovepress.com/role-of-olmesartan-in-combination-therapy-in-blood-pressure-control-an-a4994 |
| work_keys_str_mv | AT carlosmferrario roleofolmesartanincombinationtherapyinbloodpressurecontrolandvascularfunction AT ronalddsmith roleofolmesartanincombinationtherapyinbloodpressurecontrolandvascularfunction |