Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review
Patients with chronic kidney disease (CKD) and dialysis have higher mortality than those without, and cardiovascular disease (CVD) is the main cause of death. As CVD is caused by several mechanisms, insulin resistance plays an important role in CVD. This review summarizes the importance and mechanis...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/12/4349 |
| _version_ | 1797501749064368128 |
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| author | Akio Nakashima Kazuhiko Kato Ichiro Ohkido Takashi Yokoo |
| author_facet | Akio Nakashima Kazuhiko Kato Ichiro Ohkido Takashi Yokoo |
| author_sort | Akio Nakashima |
| collection | DOAJ |
| description | Patients with chronic kidney disease (CKD) and dialysis have higher mortality than those without, and cardiovascular disease (CVD) is the main cause of death. As CVD is caused by several mechanisms, insulin resistance plays an important role in CVD. This review summarizes the importance and mechanism of insulin resistance in CKD and discusses the current evidence regarding insulin resistance in patients with CKD and dialysis. Insulin resistance has been reported to influence endothelial dysfunction, plaque formation, hypertension, and dyslipidemia. A recent study also reported an association between insulin resistance and cognitive dysfunction, non-alcoholic fatty liver disease, polycystic ovary syndrome, and malignancy. Insulin resistance increases as renal function decrease in patients with CKD and dialysis. Several mechanisms increase insulin resistance in patients with CKD, such as chronic inflammation, oxidative stress, obesity, and mineral bone disorder. There is the possibility that insulin resistance is the potential future target of treatment in patients with CKD. |
| first_indexed | 2024-03-10T03:24:01Z |
| format | Article |
| id | doaj.art-079b6948d01f4031ba434d925f4af545 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T03:24:01Z |
| publishDate | 2021-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-079b6948d01f4031ba434d925f4af5452023-11-23T09:56:29ZengMDPI AGNutrients2072-66432021-12-011312434910.3390/nu13124349Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A ReviewAkio Nakashima0Kazuhiko Kato1Ichiro Ohkido2Takashi Yokoo3Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, JapanDivision of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, JapanPatients with chronic kidney disease (CKD) and dialysis have higher mortality than those without, and cardiovascular disease (CVD) is the main cause of death. As CVD is caused by several mechanisms, insulin resistance plays an important role in CVD. This review summarizes the importance and mechanism of insulin resistance in CKD and discusses the current evidence regarding insulin resistance in patients with CKD and dialysis. Insulin resistance has been reported to influence endothelial dysfunction, plaque formation, hypertension, and dyslipidemia. A recent study also reported an association between insulin resistance and cognitive dysfunction, non-alcoholic fatty liver disease, polycystic ovary syndrome, and malignancy. Insulin resistance increases as renal function decrease in patients with CKD and dialysis. Several mechanisms increase insulin resistance in patients with CKD, such as chronic inflammation, oxidative stress, obesity, and mineral bone disorder. There is the possibility that insulin resistance is the potential future target of treatment in patients with CKD.https://www.mdpi.com/2072-6643/13/12/4349chronic kidney diseaseinsulin resistancevitamin Dcardiovascular disease |
| spellingShingle | Akio Nakashima Kazuhiko Kato Ichiro Ohkido Takashi Yokoo Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review Nutrients chronic kidney disease insulin resistance vitamin D cardiovascular disease |
| title | Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review |
| title_full | Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review |
| title_fullStr | Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review |
| title_full_unstemmed | Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review |
| title_short | Role and Treatment of Insulin Resistance in Patients with Chronic Kidney Disease: A Review |
| title_sort | role and treatment of insulin resistance in patients with chronic kidney disease a review |
| topic | chronic kidney disease insulin resistance vitamin D cardiovascular disease |
| url | https://www.mdpi.com/2072-6643/13/12/4349 |
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