Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon
Human T-lymphotropic viruses 1 and 2 (HTLV-1 and HTLV-2) are retroviruses that originated on the African continent and dispersed throughout other continents through human migratory flows. This study describes the prevalence of HTLV-1 and HTLV-2 infection in residents of 11 quilombo remnant communiti...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Public Health |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2022.871865/full |
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| author | Wandrey Roberto dos Santos Brito Wandrey Roberto dos Santos Brito Greice de Lemos Cardoso-Costa Greice de Lemos Cardoso-Costa Lourival Marques Roland Junior Lourival Marques Roland Junior Keise Adrielle Santos Pereira Keise Adrielle Santos Pereira Felipe Teixeira Lopes Felipe Teixeira Lopes Bernardo Cintra dos Santos Aline Cecy Rocha de Lima Aline Cecy Rocha de Lima Isabella Nogueira Abreu Isabella Nogueira Abreu Carlos Neandro Cordeiro Lima Carlos Neandro Cordeiro Lima Sandra Souza Lima Izaura M. Vieira Cayres Vallinoto Izaura M. Vieira Cayres Vallinoto Eduardo José Melo dos Santos Eduardo José Melo dos Santos João Farias Guerreiro Antonio Carlos Rosário Vallinoto Antonio Carlos Rosário Vallinoto |
| author_facet | Wandrey Roberto dos Santos Brito Wandrey Roberto dos Santos Brito Greice de Lemos Cardoso-Costa Greice de Lemos Cardoso-Costa Lourival Marques Roland Junior Lourival Marques Roland Junior Keise Adrielle Santos Pereira Keise Adrielle Santos Pereira Felipe Teixeira Lopes Felipe Teixeira Lopes Bernardo Cintra dos Santos Aline Cecy Rocha de Lima Aline Cecy Rocha de Lima Isabella Nogueira Abreu Isabella Nogueira Abreu Carlos Neandro Cordeiro Lima Carlos Neandro Cordeiro Lima Sandra Souza Lima Izaura M. Vieira Cayres Vallinoto Izaura M. Vieira Cayres Vallinoto Eduardo José Melo dos Santos Eduardo José Melo dos Santos João Farias Guerreiro Antonio Carlos Rosário Vallinoto Antonio Carlos Rosário Vallinoto |
| author_sort | Wandrey Roberto dos Santos Brito |
| collection | DOAJ |
| description | Human T-lymphotropic viruses 1 and 2 (HTLV-1 and HTLV-2) are retroviruses that originated on the African continent and dispersed throughout other continents through human migratory flows. This study describes the prevalence of HTLV-1 and HTLV-2 infection in residents of 11 quilombo remnant communities in the state of Pará, Brazil, and the associated risk factors. A total of 859 individuals (334 men and 525 women), aged between 7 and 91 years, participated in the study. All subjects answered a questionnaire with questions on sociodemographic characteristics and on risk factors associated with HTLV infection, and blood samples were collected and separated into plasma and leukocytes. An immunoenzymatic assay (ELISA; Murex HTLV-I+II, DiaSorin, Dartford, UK) was used as a screening test, and positive samples were subjected to line immunoassay confirmatory tests (Inno-LIA HTLV I/II Score FUJIREBIO) and DNA extraction for subsequent real-time PCR to differentiate the viral type. Four of the 859 individuals were seropositive for HTLV. HTLV-1 infection was confirmed in one individual from the Itamoari community (0.92%), and HTLV-2 infection was confirmed in two individuals from São Benedito (3.17%) and in one individual from Arimandeua (2.22%). Blood transfusion was the only risk factor associated with HTLV infection in this study. This study reports the occurrence of HTLV-1 and HTLV-2 in quilombo remnant communities in the state of Pará. Considering the African origin of the virus and its introduction into Brazil from the slave trade, the continued evaluation of quilombola communities in the state of Pará is essential to better characterize the distribution of infections in these populations and to create public health policies for the control of the spread of the virus and associated diseases. |
| first_indexed | 2024-12-13T01:38:39Z |
| format | Article |
| id | doaj.art-079d1655391a4ffcbd46a4d86db48984 |
| institution | Directory Open Access Journal |
| issn | 2296-2565 |
| language | English |
| last_indexed | 2024-12-13T01:38:39Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Public Health |
| spelling | doaj.art-079d1655391a4ffcbd46a4d86db489842022-12-22T00:03:50ZengFrontiers Media S.A.Frontiers in Public Health2296-25652022-03-011010.3389/fpubh.2022.871865871865Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian AmazonWandrey Roberto dos Santos Brito0Wandrey Roberto dos Santos Brito1Greice de Lemos Cardoso-Costa2Greice de Lemos Cardoso-Costa3Lourival Marques Roland Junior4Lourival Marques Roland Junior5Keise Adrielle Santos Pereira6Keise Adrielle Santos Pereira7Felipe Teixeira Lopes8Felipe Teixeira Lopes9Bernardo Cintra dos Santos10Aline Cecy Rocha de Lima11Aline Cecy Rocha de Lima12Isabella Nogueira Abreu13Isabella Nogueira Abreu14Carlos Neandro Cordeiro Lima15Carlos Neandro Cordeiro Lima16Sandra Souza Lima17Izaura M. Vieira Cayres Vallinoto18Izaura M. Vieira Cayres Vallinoto19Eduardo José Melo dos Santos20Eduardo José Melo dos Santos21João Farias Guerreiro22Antonio Carlos Rosário Vallinoto23Antonio Carlos Rosário Vallinoto24Laboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Genetics of Complex Diseases, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Human and Medical Genetics, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilLaboratory of Virology, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilPostgraduate Program in Biology of Infectious and Parasitic Agents, Institute of Biological Sciences, Federal University of Pará, Belém, BrazilHuman T-lymphotropic viruses 1 and 2 (HTLV-1 and HTLV-2) are retroviruses that originated on the African continent and dispersed throughout other continents through human migratory flows. This study describes the prevalence of HTLV-1 and HTLV-2 infection in residents of 11 quilombo remnant communities in the state of Pará, Brazil, and the associated risk factors. A total of 859 individuals (334 men and 525 women), aged between 7 and 91 years, participated in the study. All subjects answered a questionnaire with questions on sociodemographic characteristics and on risk factors associated with HTLV infection, and blood samples were collected and separated into plasma and leukocytes. An immunoenzymatic assay (ELISA; Murex HTLV-I+II, DiaSorin, Dartford, UK) was used as a screening test, and positive samples were subjected to line immunoassay confirmatory tests (Inno-LIA HTLV I/II Score FUJIREBIO) and DNA extraction for subsequent real-time PCR to differentiate the viral type. Four of the 859 individuals were seropositive for HTLV. HTLV-1 infection was confirmed in one individual from the Itamoari community (0.92%), and HTLV-2 infection was confirmed in two individuals from São Benedito (3.17%) and in one individual from Arimandeua (2.22%). Blood transfusion was the only risk factor associated with HTLV infection in this study. This study reports the occurrence of HTLV-1 and HTLV-2 in quilombo remnant communities in the state of Pará. Considering the African origin of the virus and its introduction into Brazil from the slave trade, the continued evaluation of quilombola communities in the state of Pará is essential to better characterize the distribution of infections in these populations and to create public health policies for the control of the spread of the virus and associated diseases.https://www.frontiersin.org/articles/10.3389/fpubh.2022.871865/fullHTLV-1/2Amazonquilombosepidemiologyvulnerable population |
| spellingShingle | Wandrey Roberto dos Santos Brito Wandrey Roberto dos Santos Brito Greice de Lemos Cardoso-Costa Greice de Lemos Cardoso-Costa Lourival Marques Roland Junior Lourival Marques Roland Junior Keise Adrielle Santos Pereira Keise Adrielle Santos Pereira Felipe Teixeira Lopes Felipe Teixeira Lopes Bernardo Cintra dos Santos Aline Cecy Rocha de Lima Aline Cecy Rocha de Lima Isabella Nogueira Abreu Isabella Nogueira Abreu Carlos Neandro Cordeiro Lima Carlos Neandro Cordeiro Lima Sandra Souza Lima Izaura M. Vieira Cayres Vallinoto Izaura M. Vieira Cayres Vallinoto Eduardo José Melo dos Santos Eduardo José Melo dos Santos João Farias Guerreiro Antonio Carlos Rosário Vallinoto Antonio Carlos Rosário Vallinoto Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon Frontiers in Public Health HTLV-1/2 Amazon quilombos epidemiology vulnerable population |
| title | Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon |
| title_full | Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon |
| title_fullStr | Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon |
| title_full_unstemmed | Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon |
| title_short | Prevalence and Risk Factors for HTLV-1/2 Infection in Quilombo Remnant Communities Living in the Brazilian Amazon |
| title_sort | prevalence and risk factors for htlv 1 2 infection in quilombo remnant communities living in the brazilian amazon |
| topic | HTLV-1/2 Amazon quilombos epidemiology vulnerable population |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2022.871865/full |
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