IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection

IL-17RA-Signaling Modulates CD8+ T Cell Survival and Exhaustion During Trypanosoma cruzi Infection

The IL-17 family contributes to host defense against many intracellular pathogens by mechanisms that are not fully understood. CD8+ T lymphocytes are key elements against intracellular microbes, and their survival and ability to mount cytotoxic responses are orchestrated by several cytokines. Here,...

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Bibliographic Details
Main Authors: Jimena Tosello Boari, Cintia L. Araujo Furlan, Facundo Fiocca Vernengo, Constanza Rodriguez, María C. Ramello, María C. Amezcua Vesely, Melisa Gorosito Serrán, Nicolás G. Nuñez, Wilfrid Richer, Eliane Piaggio, Carolina L. Montes, Adriana Gruppi, Eva V. Acosta Rodríguez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
IL-17
chagas disease
immunity
cellular
CD8+ T cells
exhausted T cells
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02347/full

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