Dysregulation of complement system in neuropsychiatric disorders: A mini review
Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorder...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-12-01
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| Series: | Biomarkers in Neuropsychiatry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666144622000119 |
| _version_ | 1811178771574685696 |
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| author | Danny Perez Sierra Ashutosh Tripathi Anilkumar Pillai |
| author_facet | Danny Perez Sierra Ashutosh Tripathi Anilkumar Pillai |
| author_sort | Danny Perez Sierra |
| collection | DOAJ |
| description | Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorders including schizophrenia and autism spectrum disorder as well as in mood disorders. A number of clinical as well as genetic studies suggest the role of complement proteins in the cortical thinning and excessive synaptic pruning frequently associated with schizophrenia. The changes in complement proteins are also associated with the pathophysiology of autism spectrum disorder, major depressive disorder and bipolar disorder, but warrant further research. In addition, rodent models suggest a strong case for complement system in anxiety-like behavior. In this article, we review the recent findings on the role of complement system in neuropsychiatric disorders. The possible uses for future complement targeted therapies are also discussed. |
| first_indexed | 2024-04-11T06:23:37Z |
| format | Article |
| id | doaj.art-079e9dc490534da4bec03d8b9a7605a0 |
| institution | Directory Open Access Journal |
| issn | 2666-1446 |
| language | English |
| last_indexed | 2024-04-11T06:23:37Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomarkers in Neuropsychiatry |
| spelling | doaj.art-079e9dc490534da4bec03d8b9a7605a02022-12-22T04:40:27ZengElsevierBiomarkers in Neuropsychiatry2666-14462022-12-017100056Dysregulation of complement system in neuropsychiatric disorders: A mini reviewDanny Perez Sierra0Ashutosh Tripathi1Anilkumar Pillai2Pathophysiology of Neuropsychiatric Disorders Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USAPathophysiology of Neuropsychiatric Disorders Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USAPathophysiology of Neuropsychiatric Disorders Program, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Research and Development, Charlie Norwood VA Medical Center, Augusta, GA, USA; Department of Psychiatry and Health Behavior, Medical College of Georgia, Augusta University, Augusta, GA, USA; Correspondence to: Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA.Complement system is one of the most important defense mechanisms of the innate immune system. In addition to their roles in immune regulation, complement proteins are also involved in neurodevelopment and adult brain plasticity. Complement dysregulation has been shown in neurodevelopmental disorders including schizophrenia and autism spectrum disorder as well as in mood disorders. A number of clinical as well as genetic studies suggest the role of complement proteins in the cortical thinning and excessive synaptic pruning frequently associated with schizophrenia. The changes in complement proteins are also associated with the pathophysiology of autism spectrum disorder, major depressive disorder and bipolar disorder, but warrant further research. In addition, rodent models suggest a strong case for complement system in anxiety-like behavior. In this article, we review the recent findings on the role of complement system in neuropsychiatric disorders. The possible uses for future complement targeted therapies are also discussed.http://www.sciencedirect.com/science/article/pii/S2666144622000119ComplementImmune systemDepressionSchizophreniaASDSynaptic plasticity |
| spellingShingle | Danny Perez Sierra Ashutosh Tripathi Anilkumar Pillai Dysregulation of complement system in neuropsychiatric disorders: A mini review Biomarkers in Neuropsychiatry Complement Immune system Depression Schizophrenia ASD Synaptic plasticity |
| title | Dysregulation of complement system in neuropsychiatric disorders: A mini review |
| title_full | Dysregulation of complement system in neuropsychiatric disorders: A mini review |
| title_fullStr | Dysregulation of complement system in neuropsychiatric disorders: A mini review |
| title_full_unstemmed | Dysregulation of complement system in neuropsychiatric disorders: A mini review |
| title_short | Dysregulation of complement system in neuropsychiatric disorders: A mini review |
| title_sort | dysregulation of complement system in neuropsychiatric disorders a mini review |
| topic | Complement Immune system Depression Schizophrenia ASD Synaptic plasticity |
| url | http://www.sciencedirect.com/science/article/pii/S2666144622000119 |
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