Research progress in small fiber neuropathy associated with Sjogren's syndrome
Small fiber neuropathy (SFN) in peripheral neuropathies is the most common neuropathy associated with Sjogren's syndrome (SS). Small fiber neuropathy is a neuropathy that specifically involves myelinated Aδ and unmyelinated c-fibers, with abnormal neurophysiology and/or reduced intraepidermal n...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
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editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology
2023-10-01
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| Series: | Pifu-xingbing zhenliaoxue zazhi |
| Subjects: | |
| Online Access: | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.012 |
| _version_ | 1797373996350570496 |
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| author | Liying XU Jiayu ZHANG Erpeng WANG Yuxin LIU Chao YUAN |
| author_facet | Liying XU Jiayu ZHANG Erpeng WANG Yuxin LIU Chao YUAN |
| author_sort | Liying XU |
| collection | DOAJ |
| description | Small fiber neuropathy (SFN) in peripheral neuropathies is the most common neuropathy associated with Sjogren's syndrome (SS). Small fiber neuropathy is a neuropathy that specifically involves myelinated Aδ and unmyelinated c-fibers, with abnormal neurophysiology and/or reduced intraepidermal nerve fiber density in the skin biopsy. Patients with Sjogren's syndrome complicated with small fiber neuropathy often present with painful and burning sensation, accompanied by autonomic dysfunction. In these patients, neurologic clinical manifestations may precede the diagnosis of Sjogren's syndrome. Thus, early diagnosis and treatment may help to reduce the suffering of the patients. This article reviews the research progress in small fiber neuropathy associated with Sjogren's syndrome, including the pathological basis, possible molecular mechanisms, clinical symptoms, the diagnosis and treatment in order to benefit the research, diagnosis and management of this disease. |
| first_indexed | 2024-03-08T18:59:30Z |
| format | Article |
| id | doaj.art-07a0357abf0741c68a951ba1721d1d1f |
| institution | Directory Open Access Journal |
| issn | 1674-8468 |
| language | zho |
| last_indexed | 2024-03-08T18:59:30Z |
| publishDate | 2023-10-01 |
| publisher | editoiral office of Journal of Diagnosis and Therapy on Dermato-venereology |
| record_format | Article |
| series | Pifu-xingbing zhenliaoxue zazhi |
| spelling | doaj.art-07a0357abf0741c68a951ba1721d1d1f2023-12-28T06:54:48Zzhoeditoiral office of Journal of Diagnosis and Therapy on Dermato-venereologyPifu-xingbing zhenliaoxue zazhi1674-84682023-10-0130545545910.3969/j.issn.1674-8468.2023.05.012Research progress in small fiber neuropathy associated with Sjogren's syndromeLiying XU0Jiayu ZHANG1Erpeng WANG2Yuxin LIU3Chao YUAN4Nanfang Hospital, Southern Medical University, Guangzhou 510510, ChinaNanfang Hospital, Southern Medical University, Guangzhou 510510, ChinaSouthern Medical University, Guangzhou 510510, ChinaSouthern Medical University, Guangzhou 510510, ChinaNanfang Hospital, Southern Medical University, Guangzhou 510510, ChinaSmall fiber neuropathy (SFN) in peripheral neuropathies is the most common neuropathy associated with Sjogren's syndrome (SS). Small fiber neuropathy is a neuropathy that specifically involves myelinated Aδ and unmyelinated c-fibers, with abnormal neurophysiology and/or reduced intraepidermal nerve fiber density in the skin biopsy. Patients with Sjogren's syndrome complicated with small fiber neuropathy often present with painful and burning sensation, accompanied by autonomic dysfunction. In these patients, neurologic clinical manifestations may precede the diagnosis of Sjogren's syndrome. Thus, early diagnosis and treatment may help to reduce the suffering of the patients. This article reviews the research progress in small fiber neuropathy associated with Sjogren's syndrome, including the pathological basis, possible molecular mechanisms, clinical symptoms, the diagnosis and treatment in order to benefit the research, diagnosis and management of this disease.http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.012sjogren's syndromesmall fiber neuropathyperipheral neuropathytreatment |
| spellingShingle | Liying XU Jiayu ZHANG Erpeng WANG Yuxin LIU Chao YUAN Research progress in small fiber neuropathy associated with Sjogren's syndrome Pifu-xingbing zhenliaoxue zazhi sjogren's syndrome small fiber neuropathy peripheral neuropathy treatment |
| title | Research progress in small fiber neuropathy associated with Sjogren's syndrome |
| title_full | Research progress in small fiber neuropathy associated with Sjogren's syndrome |
| title_fullStr | Research progress in small fiber neuropathy associated with Sjogren's syndrome |
| title_full_unstemmed | Research progress in small fiber neuropathy associated with Sjogren's syndrome |
| title_short | Research progress in small fiber neuropathy associated with Sjogren's syndrome |
| title_sort | research progress in small fiber neuropathy associated with sjogren s syndrome |
| topic | sjogren's syndrome small fiber neuropathy peripheral neuropathy treatment |
| url | http://pfxbzlx.gdvdc.com/EN/10.3969/j.issn.1674-8468.2023.05.012 |
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