The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar
Leptin is secreted by adipose tissue and expressed in several organs, including the placenta. We investigated the influence of leptin in maternal blood on leptin expression and concentration in the placenta and umbilical cord and its influence on fetal weight and conditions at the time of birth. Twe...
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MDPI AG
2024-03-01
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| Series: | Obesities |
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| Online Access: | https://www.mdpi.com/2673-4168/4/1/3 |
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| author | Daniela G. M. Fonseca Maria-Carmen N. Souza-Carmo Raquel N. Ruas Solange S. Pereira Lílian Goncalves Teixeira e Jacqueline I. Alvarez-Leite |
| author_facet | Daniela G. M. Fonseca Maria-Carmen N. Souza-Carmo Raquel N. Ruas Solange S. Pereira Lílian Goncalves Teixeira e Jacqueline I. Alvarez-Leite |
| author_sort | Daniela G. M. Fonseca |
| collection | DOAJ |
| description | Leptin is secreted by adipose tissue and expressed in several organs, including the placenta. We investigated the influence of leptin in maternal blood on leptin expression and concentration in the placenta and umbilical cord and its influence on fetal weight and conditions at the time of birth. Twenty-five parturients were recruited, and after childbirth, placental tissue fragments, umbilical arteries, and vein blood were collected. According to leptin concentration in maternal peripheral blood, parturients were divided into low and high leptin groups. Mothers in the high-leptin group had higher age, pre-pregnancy weight, pre-pregnancy BMI, and weight in late pregnancy than mothers in the low-leptin group. Children of mothers in the high-leptin group presented an Apgar score modestly lower than those of the low-leptin group. No differences were observed in leptin concentrations in the umbilical artery and vein. However, the leptin retained in the fetus increased in the high-leptin group compared to the low-leptin group. We observed a negative correlation between fetal leptin retained and maternal age in the low-leptin group. In the high-leptin group, placental leptin concentration was positively correlated with maternal weight in late pregnancy. Nonetheless, the expression of the leptin receptor (Ob-Rb) was negatively correlated with newborn length. In conclusion, this study found a positive correlation between maternal leptin levels and maternal pre-pregnancy weight, BMI, and fetal birth weight. These findings suggest a potential role of leptin in maternal weight regulation during pregnancy and fetal growth. |
| first_indexed | 2024-04-24T17:55:43Z |
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| issn | 2673-4168 |
| language | English |
| last_indexed | 2024-04-24T17:55:43Z |
| publishDate | 2024-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Obesities |
| spelling | doaj.art-07a064c3bed94063b5318ff2b6c48e792024-03-27T13:58:27ZengMDPI AGObesities2673-41682024-03-0141243410.3390/obesities4010003The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and ApgarDaniela G. M. Fonseca0Maria-Carmen N. Souza-Carmo1Raquel N. Ruas2Solange S. Pereira3Lílian Goncalves Teixeira4e Jacqueline I. Alvarez-Leite5Departamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilDepartamento de Nutrição e Saúde, Universidade Federal de Viçosa, Viçosa 36570-900, BrazilDepartamento de Nutrição, Universidade Federal de Lavras, Lavras 37200-000, BrazilDepartamento de Bioquímica e Imunologia, Universidade Federal de Minas Gerais, Belo Horizonte 31270-901, BrazilLeptin is secreted by adipose tissue and expressed in several organs, including the placenta. We investigated the influence of leptin in maternal blood on leptin expression and concentration in the placenta and umbilical cord and its influence on fetal weight and conditions at the time of birth. Twenty-five parturients were recruited, and after childbirth, placental tissue fragments, umbilical arteries, and vein blood were collected. According to leptin concentration in maternal peripheral blood, parturients were divided into low and high leptin groups. Mothers in the high-leptin group had higher age, pre-pregnancy weight, pre-pregnancy BMI, and weight in late pregnancy than mothers in the low-leptin group. Children of mothers in the high-leptin group presented an Apgar score modestly lower than those of the low-leptin group. No differences were observed in leptin concentrations in the umbilical artery and vein. However, the leptin retained in the fetus increased in the high-leptin group compared to the low-leptin group. We observed a negative correlation between fetal leptin retained and maternal age in the low-leptin group. In the high-leptin group, placental leptin concentration was positively correlated with maternal weight in late pregnancy. Nonetheless, the expression of the leptin receptor (Ob-Rb) was negatively correlated with newborn length. In conclusion, this study found a positive correlation between maternal leptin levels and maternal pre-pregnancy weight, BMI, and fetal birth weight. These findings suggest a potential role of leptin in maternal weight regulation during pregnancy and fetal growth.https://www.mdpi.com/2673-4168/4/1/3leptinpregnancyobesityplacentanewborninflammation |
| spellingShingle | Daniela G. M. Fonseca Maria-Carmen N. Souza-Carmo Raquel N. Ruas Solange S. Pereira Lílian Goncalves Teixeira e Jacqueline I. Alvarez-Leite The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar Obesities leptin pregnancy obesity placenta newborn inflammation |
| title | The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar |
| title_full | The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar |
| title_fullStr | The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar |
| title_full_unstemmed | The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar |
| title_short | The Potential Role of Leptin in the Regulation of Maternal Weight during Pregnancy and Its Impact on Neonate Weight and Apgar |
| title_sort | potential role of leptin in the regulation of maternal weight during pregnancy and its impact on neonate weight and apgar |
| topic | leptin pregnancy obesity placenta newborn inflammation |
| url | https://www.mdpi.com/2673-4168/4/1/3 |
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