A Substituted Diphenyl Amide Based Novel Scaffold Inhibits Staphylococcus aureus Virulence in a Galleria mellonella Infection Model

A Substituted Diphenyl Amide Based Novel Scaffold Inhibits Staphylococcus aureus Virulence in a Galleria mellonella Infection Model

Antimicrobial compounds can combat microbes through modulating host immune defense, inhibiting bacteria survival and growth, or through impeding or inhibiting virulence factors. In the present study, a panel of substituted diphenyl amide compounds previously found to disrupt bacterial quorum sensing...

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Bibliographic Details
Main Authors: Biswajit Mishra, Rajamohammed Khader, Lewis Oscar Felix, Marissa Frate, Eleftherios Mylonakis, Susan Meschwitz, Beth Burgwyn Fuchs
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial compounds
drug discovery
Galleria mellonella
quorum sensing antagonist
Staphylococcus aureus
virulence
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.723133/full

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