Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

Abstract Background Circular RNAs (circRNAs) are stable, often highly expressed RNA transcripts with potential to modulate other regulatory RNAs. A few circRNAs have been shown to bind RNA-binding proteins (RBPs); however, little is known about the prevalence and distribution of these interactions i...

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Bibliographic Details
Main Authors: Trine Line Hauge Okholm, Shashank Sathe, Samuel S. Park, Andreas Bjerregaard Kamstrup, Asta Mannstaedt Rasmussen, Archana Shankar, Zong Ming Chua, Niels Fristrup, Morten Muhlig Nielsen, Søren Vang, Lars Dyrskjøt, Stefan Aigner, Christian Kroun Damgaard, Gene W. Yeo, Jakob Skou Pedersen
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Genome Medicine
Subjects:
Circular RNAs
RNA-binding proteins
RBP sponges
circCDYL
Bladder cancer
Tumorigenesis
Online Access:https://doi.org/10.1186/s13073-020-00812-8

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