Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis
Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-existing blood vessels. The process of development of the proper vascular network is a complex process that is crucial for the vertebrate development. Several studies have defined essential roles of Hippo pathway...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-04-01
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| Series: | Frontiers in Cell and Developmental Biology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fcell.2019.00049/full |
| _version_ | 1818268947040960512 |
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| author | Gandhi T. K. Boopathy Wanjin Hong |
| author_facet | Gandhi T. K. Boopathy Wanjin Hong |
| author_sort | Gandhi T. K. Boopathy |
| collection | DOAJ |
| description | Angiogenesis is a highly coordinated process of formation of new blood vessels from pre-existing blood vessels. The process of development of the proper vascular network is a complex process that is crucial for the vertebrate development. Several studies have defined essential roles of Hippo pathway-YAP/TAZ in organ size control, tissue regeneration, and self-renewal. Thus Hippo pathway is one of the central components in tissue homeostasis. There are mounting evidences on the eminence of Hippo pathway-YAP/TAZ in angiogenesis in multiple model organisms. Hippo pathway-YAP/TAZ is now demonstrated to regulate endothelial cell proliferation, migration and survival; subsequently regulating vascular sprouting, vascular barrier formation, and vascular remodeling. Major intracellular signaling programs that regulate angiogenesis concomitantly activate YAP/TAZ to regulate key events in angiogenesis. In this review, we provide a brief overview of the recent findings in the Hippo pathway and YAP/TAZ signaling in angiogenesis. |
| first_indexed | 2024-12-12T20:46:35Z |
| format | Article |
| id | doaj.art-07a2c45d1cec46df938e7645542676c2 |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-12T20:46:35Z |
| publishDate | 2019-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-07a2c45d1cec46df938e7645542676c22022-12-22T00:12:32ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2019-04-01710.3389/fcell.2019.00049440860Role of Hippo Pathway-YAP/TAZ Signaling in AngiogenesisGandhi T. K. BoopathyWanjin HongAngiogenesis is a highly coordinated process of formation of new blood vessels from pre-existing blood vessels. The process of development of the proper vascular network is a complex process that is crucial for the vertebrate development. Several studies have defined essential roles of Hippo pathway-YAP/TAZ in organ size control, tissue regeneration, and self-renewal. Thus Hippo pathway is one of the central components in tissue homeostasis. There are mounting evidences on the eminence of Hippo pathway-YAP/TAZ in angiogenesis in multiple model organisms. Hippo pathway-YAP/TAZ is now demonstrated to regulate endothelial cell proliferation, migration and survival; subsequently regulating vascular sprouting, vascular barrier formation, and vascular remodeling. Major intracellular signaling programs that regulate angiogenesis concomitantly activate YAP/TAZ to regulate key events in angiogenesis. In this review, we provide a brief overview of the recent findings in the Hippo pathway and YAP/TAZ signaling in angiogenesis.https://www.frontiersin.org/article/10.3389/fcell.2019.00049/fullHippo pathwayYAPTAZangiogenesissignal transductionmammalian Hippo signaling |
| spellingShingle | Gandhi T. K. Boopathy Wanjin Hong Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis Frontiers in Cell and Developmental Biology Hippo pathway YAP TAZ angiogenesis signal transduction mammalian Hippo signaling |
| title | Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis |
| title_full | Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis |
| title_fullStr | Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis |
| title_full_unstemmed | Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis |
| title_short | Role of Hippo Pathway-YAP/TAZ Signaling in Angiogenesis |
| title_sort | role of hippo pathway yap taz signaling in angiogenesis |
| topic | Hippo pathway YAP TAZ angiogenesis signal transduction mammalian Hippo signaling |
| url | https://www.frontiersin.org/article/10.3389/fcell.2019.00049/full |
| work_keys_str_mv | AT gandhitkboopathy roleofhippopathwayyaptazsignalinginangiogenesis AT wanjinhong roleofhippopathwayyaptazsignalinginangiogenesis |