Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review
Autism spectrum disorder (ASD) is a basket term for neurodevelopmental disorders characterized by marked impairments in social interactions, repetitive and stereotypical behaviors, and restricted interests and activities. Subtypes include (A) disorders with known genetic abnormalities including frag...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.806876/full |
| _version_ | 1811309781449703424 |
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| author | Zhiqiang Tan Huiyi Wei Xiubao Song Wangxiang Mai Jiajian Yan Weijian Ye Xueying Ling Lu Hou Shaojuan Zhang Sen Yan Hao Xu Lu Wang |
| author_facet | Zhiqiang Tan Huiyi Wei Xiubao Song Wangxiang Mai Jiajian Yan Weijian Ye Xueying Ling Lu Hou Shaojuan Zhang Sen Yan Hao Xu Lu Wang |
| author_sort | Zhiqiang Tan |
| collection | DOAJ |
| description | Autism spectrum disorder (ASD) is a basket term for neurodevelopmental disorders characterized by marked impairments in social interactions, repetitive and stereotypical behaviors, and restricted interests and activities. Subtypes include (A) disorders with known genetic abnormalities including fragile X syndrome, Rett syndrome, and tuberous sclerosis and (B) idiopathic ASD, conditions with unknown etiologies. Positron emission tomography (PET) is a molecular imaging technology that can be utilized in vivo for dynamic and quantitative research, and is a valuable tool for exploring pathophysiological mechanisms, evaluating therapeutic efficacy, and accelerating drug development in ASD. Recently, several imaging studies on ASD have been published and physiological changes during ASD progression was disclosed by PET. This paper reviews the specific radioligands for PET imaging of critical biomarkers in ASD, and summarizes and discusses the similar and different discoveries in outcomes of previous studies. It is of great importance to identify general physiological changes in cerebral glucose metabolism, cerebral blood flow perfusion, abnormalities in neurotransmitter systems, and inflammation in the central nervous system in ASD, which may provide excellent points for further ASD research. |
| first_indexed | 2024-04-13T09:47:12Z |
| format | Article |
| id | doaj.art-07a3e4117dcf494faf154fefde138765 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-13T09:47:12Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-07a3e4117dcf494faf154fefde1387652022-12-22T02:51:42ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-04-011610.3389/fnins.2022.806876806876Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A ReviewZhiqiang Tan0Huiyi Wei1Xiubao Song2Wangxiang Mai3Jiajian Yan4Weijian Ye5Xueying Ling6Lu Hou7Shaojuan Zhang8Sen Yan9Hao Xu10Lu Wang11Center of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, ChinaDepartment of Rehabilitation Medicine, The First Affiliated Hospital of Jinan University, Jinan University, Guangzhou, ChinaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaGuangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, ChinaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaCenter of Cyclotron and PET Radiopharmaceuticals, Department of Nuclear Medicine and PET/CT-MRI Center, The First Affiliated Hospital of Jinan University, Guangzhou, ChinaAutism spectrum disorder (ASD) is a basket term for neurodevelopmental disorders characterized by marked impairments in social interactions, repetitive and stereotypical behaviors, and restricted interests and activities. Subtypes include (A) disorders with known genetic abnormalities including fragile X syndrome, Rett syndrome, and tuberous sclerosis and (B) idiopathic ASD, conditions with unknown etiologies. Positron emission tomography (PET) is a molecular imaging technology that can be utilized in vivo for dynamic and quantitative research, and is a valuable tool for exploring pathophysiological mechanisms, evaluating therapeutic efficacy, and accelerating drug development in ASD. Recently, several imaging studies on ASD have been published and physiological changes during ASD progression was disclosed by PET. This paper reviews the specific radioligands for PET imaging of critical biomarkers in ASD, and summarizes and discusses the similar and different discoveries in outcomes of previous studies. It is of great importance to identify general physiological changes in cerebral glucose metabolism, cerebral blood flow perfusion, abnormalities in neurotransmitter systems, and inflammation in the central nervous system in ASD, which may provide excellent points for further ASD research.https://www.frontiersin.org/articles/10.3389/fnins.2022.806876/fullautism spectrum disorderASDneuroimagingpositron emission tomographyPETradioligands |
| spellingShingle | Zhiqiang Tan Huiyi Wei Xiubao Song Wangxiang Mai Jiajian Yan Weijian Ye Xueying Ling Lu Hou Shaojuan Zhang Sen Yan Hao Xu Lu Wang Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review Frontiers in Neuroscience autism spectrum disorder ASD neuroimaging positron emission tomography PET radioligands |
| title | Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review |
| title_full | Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review |
| title_fullStr | Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review |
| title_full_unstemmed | Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review |
| title_short | Positron Emission Tomography in the Neuroimaging of Autism Spectrum Disorder: A Review |
| title_sort | positron emission tomography in the neuroimaging of autism spectrum disorder a review |
| topic | autism spectrum disorder ASD neuroimaging positron emission tomography PET radioligands |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.806876/full |
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