The effective function of circular RNA in colorectal cancer
Abstract Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tum...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-09-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-021-02196-0 |
| _version_ | 1819240083737280512 |
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| author | Mandana Ameli-Mojarad Melika Ameli-Mojarad Mahrooyeh Hadizadeh Chris Young Hosna Babini Ehsan Nazemalhosseini-Mojarad Maziar Ashrafian Bonab |
| author_facet | Mandana Ameli-Mojarad Melika Ameli-Mojarad Mahrooyeh Hadizadeh Chris Young Hosna Babini Ehsan Nazemalhosseini-Mojarad Maziar Ashrafian Bonab |
| author_sort | Mandana Ameli-Mojarad |
| collection | DOAJ |
| description | Abstract Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC. |
| first_indexed | 2024-12-23T14:02:23Z |
| format | Article |
| id | doaj.art-07a44dfef7464fe29bb0bc4b956787e9 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-23T14:02:23Z |
| publishDate | 2021-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-07a44dfef7464fe29bb0bc4b956787e92022-12-21T17:44:16ZengBMCCancer Cell International1475-28672021-09-0121111610.1186/s12935-021-02196-0The effective function of circular RNA in colorectal cancerMandana Ameli-Mojarad0Melika Ameli-Mojarad1Mahrooyeh Hadizadeh2Chris Young3Hosna Babini4Ehsan Nazemalhosseini-Mojarad5Maziar Ashrafian Bonab6Department of Biology, Faculty of Basic Science, Kharrazi UniversityDepartment of Biology, Faculty of Basic Science, Kharrazi UniversitySchool of Medicine, University of SunderlandInstitute of Health & Life Sciences, De Montfort UniversityDepartment of Cell & Molecular Biology, Faculty of Science, Tehran University of Medical ScienceGastroenterology and Liver Disease Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical SciencesSchool of Medicine, University of SunderlandAbstract Colorectal cancer (CRC) is the 3rd most common type of cancer worldwide. Late detection plays role in one-third of annual mortality due to CRC. Therefore, it is essential to find a precise and optimal diagnostic and prognostic biomarker for the identification and treatment of colorectal tumorigenesis. Covalently closed, circular RNAs (circRNAs) are a class of non-coding RNAs, which can have the same function as microRNA (miRNA) sponges, as regulators of splicing and transcription, and as interactors with RNA-binding proteins (RBPs). Therefore, circRNAs have been investigated as specific targets for diagnostic and prognostic detection of CRC. These non-coding RNAs are also linked to metastasis, proliferation, differentiation, migration, angiogenesis, apoptosis, and drug resistance, illustrating the importance of understanding their involvement in the molecular mechanisms of development and progression of CRC. In this review, we present a detailed summary of recent findings relating to the dysregulation of circRNAs and their potential role in CRC.https://doi.org/10.1186/s12935-021-02196-0Circular RNAColorectal cancerLong non-coding RNANoncoding RNA |
| spellingShingle | Mandana Ameli-Mojarad Melika Ameli-Mojarad Mahrooyeh Hadizadeh Chris Young Hosna Babini Ehsan Nazemalhosseini-Mojarad Maziar Ashrafian Bonab The effective function of circular RNA in colorectal cancer Cancer Cell International Circular RNA Colorectal cancer Long non-coding RNA Noncoding RNA |
| title | The effective function of circular RNA in colorectal cancer |
| title_full | The effective function of circular RNA in colorectal cancer |
| title_fullStr | The effective function of circular RNA in colorectal cancer |
| title_full_unstemmed | The effective function of circular RNA in colorectal cancer |
| title_short | The effective function of circular RNA in colorectal cancer |
| title_sort | effective function of circular rna in colorectal cancer |
| topic | Circular RNA Colorectal cancer Long non-coding RNA Noncoding RNA |
| url | https://doi.org/10.1186/s12935-021-02196-0 |
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