CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

CRIg, a tissue-resident macrophage specific immune checkpoint molecule, promotes immunological tolerance in NOD mice, via a dual role in effector and regulatory T cells

How tissue-resident macrophages (TRM) impact adaptive immune responses remains poorly understood. We report novel mechanisms by which TRMs regulate T cell activities at tissue sites. These mechanisms are mediated by the complement receptor of immunoglobulin family (CRIg). Using animal models for aut...

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Bibliographic Details
Main Authors: Xiaomei Yuan, Bi-Huei Yang, Yi Dong, Asami Yamamura, Wenxian Fu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
macrophages
T cells
immune checkpoint
immunological tolerance
inflammation
CRIg
Online Access:https://elifesciences.org/articles/29540

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