Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers
Ischemic stroke (IS) exhibits significant heterogeneity in terms of etiology and pathophysiology. Several recent studies highlight the significance of inflammation in the onset and progression of IS. White blood cell subtypes, such as neutrophils and monocytes, participate in the inflammatory respon...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-02-01
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| Series: | Neurology International |
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| Online Access: | https://www.mdpi.com/2035-8377/15/1/19 |
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| author | Aimilios Gkantzios Dimitrios Tsiptsios Vaia Karapepera Stella Karatzetzou Stratis Kiamelidis Pinelopi Vlotinou Erasmia Giannakou Evangeli Karampina Katerina Paschalidou Nikolaos Kourkoutsakis Nikolaos Papanas Nikolaos Aggelousis Konstantinos Vadikolias |
| author_facet | Aimilios Gkantzios Dimitrios Tsiptsios Vaia Karapepera Stella Karatzetzou Stratis Kiamelidis Pinelopi Vlotinou Erasmia Giannakou Evangeli Karampina Katerina Paschalidou Nikolaos Kourkoutsakis Nikolaos Papanas Nikolaos Aggelousis Konstantinos Vadikolias |
| author_sort | Aimilios Gkantzios |
| collection | DOAJ |
| description | Ischemic stroke (IS) exhibits significant heterogeneity in terms of etiology and pathophysiology. Several recent studies highlight the significance of inflammation in the onset and progression of IS. White blood cell subtypes, such as neutrophils and monocytes, participate in the inflammatory response in various ways. On the other hand, high-density lipoproteins (HDL) exhibit substantial anti-inflammatory and antioxidant actions. Consequently, novel inflammatory blood biomarkers have emerged, such as neutrophil to HDL ratio (NHR) and monocyte to HDL ratio (MHR). Literature research of two databases (MEDLINE and Scopus) was conducted to identify all relevant studies published between 1 January 2012 and 30 November 2022 dealing with NHR and MHR as biomarkers for IS prognosis. Only full-text articles published in the English language were included. Thirteen articles have been traced and are included in the present review. Our findings highlight the utility of NHR and MHR as novel stroke prognostic biomarkers, the widespread application, and the calculation of which, along with their inexpensive cost, make their clinical application extremely promising. |
| first_indexed | 2024-03-11T06:04:48Z |
| format | Article |
| id | doaj.art-07a827e528b84689ae0dcc5f414ebee1 |
| institution | Directory Open Access Journal |
| issn | 2035-8377 |
| language | English |
| last_indexed | 2024-03-11T06:04:48Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Neurology International |
| spelling | doaj.art-07a827e528b84689ae0dcc5f414ebee12023-11-17T13:02:32ZengMDPI AGNeurology International2035-83772023-02-0115130131710.3390/neurolint15010019Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic BiomarkersAimilios Gkantzios0Dimitrios Tsiptsios1Vaia Karapepera2Stella Karatzetzou3Stratis Kiamelidis4Pinelopi Vlotinou5Erasmia Giannakou6Evangeli Karampina7Katerina Paschalidou8Nikolaos Kourkoutsakis9Nikolaos Papanas10Nikolaos Aggelousis11Konstantinos Vadikolias12Neurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceRadiology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceSecond Department of Internal Medicine, Democritus University of Thrace, 68100 Alexandroupolis, GreeceDepartment of Physical Education and Sport Science, Democritus University of Thrace, 69100 Komotini, GreeceNeurology Department, Democritus University of Thrace, 68100 Alexandroupolis, GreeceIschemic stroke (IS) exhibits significant heterogeneity in terms of etiology and pathophysiology. Several recent studies highlight the significance of inflammation in the onset and progression of IS. White blood cell subtypes, such as neutrophils and monocytes, participate in the inflammatory response in various ways. On the other hand, high-density lipoproteins (HDL) exhibit substantial anti-inflammatory and antioxidant actions. Consequently, novel inflammatory blood biomarkers have emerged, such as neutrophil to HDL ratio (NHR) and monocyte to HDL ratio (MHR). Literature research of two databases (MEDLINE and Scopus) was conducted to identify all relevant studies published between 1 January 2012 and 30 November 2022 dealing with NHR and MHR as biomarkers for IS prognosis. Only full-text articles published in the English language were included. Thirteen articles have been traced and are included in the present review. Our findings highlight the utility of NHR and MHR as novel stroke prognostic biomarkers, the widespread application, and the calculation of which, along with their inexpensive cost, make their clinical application extremely promising.https://www.mdpi.com/2035-8377/15/1/19monocyte to HDL-rationeutrophil to HDL-ratioMHRNHRstroke prognosisstroke outcome |
| spellingShingle | Aimilios Gkantzios Dimitrios Tsiptsios Vaia Karapepera Stella Karatzetzou Stratis Kiamelidis Pinelopi Vlotinou Erasmia Giannakou Evangeli Karampina Katerina Paschalidou Nikolaos Kourkoutsakis Nikolaos Papanas Nikolaos Aggelousis Konstantinos Vadikolias Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers Neurology International monocyte to HDL-ratio neutrophil to HDL-ratio MHR NHR stroke prognosis stroke outcome |
| title | Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers |
| title_full | Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers |
| title_fullStr | Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers |
| title_full_unstemmed | Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers |
| title_short | Monocyte to HDL and Neutrophil to HDL Ratios as Potential Ischemic Stroke Prognostic Biomarkers |
| title_sort | monocyte to hdl and neutrophil to hdl ratios as potential ischemic stroke prognostic biomarkers |
| topic | monocyte to HDL-ratio neutrophil to HDL-ratio MHR NHR stroke prognosis stroke outcome |
| url | https://www.mdpi.com/2035-8377/15/1/19 |
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