Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar rats
Summary: This study evaluates the medicinal and therapeutic importance of aqueous pulp extract of Irvingia gabonensis (APEIG) fruit on some biochemical indices in adult male albino rats. Thirty-six adult male rats were grouped into 3 groups of 12 rats each. Group 1 was the control, while groups 2 an...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-04-01
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| Series: | Clinical Nutrition Open Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667268522000031 |
| _version_ | 1818015130569408512 |
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| author | Emeka Godwin Anaduaka Chiedozie Sylvester Ozioko Sebastine Chinweike Ugwuoke Nene Orizu Uchendu Joseph Chinedum Ndefo Dionysius Obinna Osuji Lorreta Nwakaego Ene |
| author_facet | Emeka Godwin Anaduaka Chiedozie Sylvester Ozioko Sebastine Chinweike Ugwuoke Nene Orizu Uchendu Joseph Chinedum Ndefo Dionysius Obinna Osuji Lorreta Nwakaego Ene |
| author_sort | Emeka Godwin Anaduaka |
| collection | DOAJ |
| description | Summary: This study evaluates the medicinal and therapeutic importance of aqueous pulp extract of Irvingia gabonensis (APEIG) fruit on some biochemical indices in adult male albino rats. Thirty-six adult male rats were grouped into 3 groups of 12 rats each. Group 1 was the control, while groups 2 and 3 received 100 and 200 mg/kg body weight of the extract respectively. The quantitative and qualitative phytochemical constituents present in the APEIG were alkaloids, flavonoids, and terpenoids in moderate amounts, while saponins, tannins, glycosides, sterols, and phenols were detected in trace amounts. The treatment lasted for 21 days and biochemical parameters were analyzed following standard procedures. Results obtained indicated a reduction in the bodyweight of the treated groups. The serum cholesterol, LDL, and VLDL concentrations were significantly moderated in the treatment groups, although, the serum HDL concentration was elevated dose-dependently on days 14 and 21. Alkaline phosphatase (ALP) was elevated in the treatment groups on days 7 and 14 while aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, uric acid, total protein, and albumin were not affected by the administration of (APEIG) on days 7, 14 and 21. Serum bilirubin was significantly lowered in the treatment groups on days 7, 14, and 21 while fasting blood glucose (FBS) of the treated groups was moderate. The results revealed that the administration of APEIG had promising medicinal potentials and could be harnessed in disease management. |
| first_indexed | 2024-04-14T06:53:57Z |
| format | Article |
| id | doaj.art-07a85aca6e6d41f098a08f0cb14adc9f |
| institution | Directory Open Access Journal |
| issn | 2667-2685 |
| language | English |
| last_indexed | 2024-04-14T06:53:57Z |
| publishDate | 2022-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Clinical Nutrition Open Science |
| spelling | doaj.art-07a85aca6e6d41f098a08f0cb14adc9f2022-12-22T02:06:57ZengElsevierClinical Nutrition Open Science2667-26852022-04-0142613Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar ratsEmeka Godwin Anaduaka0Chiedozie Sylvester Ozioko1Sebastine Chinweike Ugwuoke2Nene Orizu Uchendu3Joseph Chinedum Ndefo4Dionysius Obinna Osuji5Lorreta Nwakaego Ene6Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Corresponding author.Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, NigeriaDepartment of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, NigeriaDepartment of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, NigeriaDepartment of Science Laboratory Sciences, Faculty of Physical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Corresponding author.Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, NigeriaDepartment of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine University of Nigeria, Enugu Campus, Enugu State, Nigeria; Corresponding author.Summary: This study evaluates the medicinal and therapeutic importance of aqueous pulp extract of Irvingia gabonensis (APEIG) fruit on some biochemical indices in adult male albino rats. Thirty-six adult male rats were grouped into 3 groups of 12 rats each. Group 1 was the control, while groups 2 and 3 received 100 and 200 mg/kg body weight of the extract respectively. The quantitative and qualitative phytochemical constituents present in the APEIG were alkaloids, flavonoids, and terpenoids in moderate amounts, while saponins, tannins, glycosides, sterols, and phenols were detected in trace amounts. The treatment lasted for 21 days and biochemical parameters were analyzed following standard procedures. Results obtained indicated a reduction in the bodyweight of the treated groups. The serum cholesterol, LDL, and VLDL concentrations were significantly moderated in the treatment groups, although, the serum HDL concentration was elevated dose-dependently on days 14 and 21. Alkaline phosphatase (ALP) was elevated in the treatment groups on days 7 and 14 while aspartate aminotransferase (AST), alanine aminotransferase (ALT), creatinine, urea, uric acid, total protein, and albumin were not affected by the administration of (APEIG) on days 7, 14 and 21. Serum bilirubin was significantly lowered in the treatment groups on days 7, 14, and 21 while fasting blood glucose (FBS) of the treated groups was moderate. The results revealed that the administration of APEIG had promising medicinal potentials and could be harnessed in disease management.http://www.sciencedirect.com/science/article/pii/S2667268522000031Irvingia gabonensisAlkaline phosphataseUreaCreatinineBilirubin |
| spellingShingle | Emeka Godwin Anaduaka Chiedozie Sylvester Ozioko Sebastine Chinweike Ugwuoke Nene Orizu Uchendu Joseph Chinedum Ndefo Dionysius Obinna Osuji Lorreta Nwakaego Ene Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar rats Clinical Nutrition Open Science Irvingia gabonensis Alkaline phosphatase Urea Creatinine Bilirubin |
| title | Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar rats |
| title_full | Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar rats |
| title_fullStr | Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar rats |
| title_full_unstemmed | Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar rats |
| title_short | Biochemical changes associated with the administration of aqueous pulp extract of Irvingia gabonensis fruit on adult male Wistar rats |
| title_sort | biochemical changes associated with the administration of aqueous pulp extract of irvingia gabonensis fruit on adult male wistar rats |
| topic | Irvingia gabonensis Alkaline phosphatase Urea Creatinine Bilirubin |
| url | http://www.sciencedirect.com/science/article/pii/S2667268522000031 |
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