Generation of functional hepatocytes by forward programming with nuclear receptors

Generation of functional hepatocytes by forward programming with nuclear receptors

Production of large quantities of hepatocytes remains a major challenge for a number of clinical applications in the biomedical field. Directed differentiation of human pluripotent stem cells (hPSCs) into hepatocyte-like cells (HLCs) provides an advantageous solution and a number of protocols have b...

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Bibliographic Details
Main Authors: Rute A Tomaz, Ekaterini D Zacharis, Fabian Bachinger, Annabelle Wurmser, Daniel Yamamoto, Sandra Petrus-Reurer, Carola M Morell, Dominika Dziedzicka, Brandon T Wesley, Imbisaat Geti, Charis-Patricia Segeritz, Miguel C de Brito, Mariya Chhatriwala, Daniel Ortmann, Kourosh Saeb-Parsy, Ludovic Vallier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-08-01
Series:eLife
Subjects:
forward programming
hepatocytes
pluripotent stem cells
Online Access:https://elifesciences.org/articles/71591

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