Identification of genetic effects underlying type 2 diabetes in South Asian and European populations
Marie Loh, Weihua Zhang et al. use a genome-wide association study meta-analysis to examine variants associated with Type 2 diabetes (T2D) in South Asian and European ancestry cohorts. Their results provide further insights into the genetic mechanisms underlying T2D across ancestral populations.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Communications Biology |
| Online Access: | https://doi.org/10.1038/s42003-022-03248-5 |
| _version_ | 1811291055653388288 |
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| author | Marie Loh Weihua Zhang Hong Kiat Ng Katharina Schmid Amel Lamri Lin Tong Meraj Ahmad Jung-Jin Lee Maggie C. Y. Ng Lauren E. Petty Cassandra N. Spracklen Fumihiko Takeuchi Md. Tariqul Islam Farzana Jasmine Anuradhani Kasturiratne Muhammad Kibriya Karen L. Mohlke Guillaume Paré Gauri Prasad Mohammad Shahriar Miao Ling Chee H. Janaka de Silva James C. Engert Hertzel C. Gerstein K. Radha Mani Charumathi Sabanayagam Marijana Vujkovic Ananda R. Wickremasinghe Tien Yin Wong Chittaranjan S. Yajnik Salim Yusuf Habibul Ahsan Dwaipayan Bharadwaj Sonia S. Anand Jennifer E. Below Michael Boehnke Donald W. Bowden Giriraj R. Chandak Ching-Yu Cheng Norihiro Kato Anubha Mahajan Xueling Sim Mark I. McCarthy Andrew P. Morris Jaspal S. Kooner Danish Saleheen John C. Chambers |
| author_facet | Marie Loh Weihua Zhang Hong Kiat Ng Katharina Schmid Amel Lamri Lin Tong Meraj Ahmad Jung-Jin Lee Maggie C. Y. Ng Lauren E. Petty Cassandra N. Spracklen Fumihiko Takeuchi Md. Tariqul Islam Farzana Jasmine Anuradhani Kasturiratne Muhammad Kibriya Karen L. Mohlke Guillaume Paré Gauri Prasad Mohammad Shahriar Miao Ling Chee H. Janaka de Silva James C. Engert Hertzel C. Gerstein K. Radha Mani Charumathi Sabanayagam Marijana Vujkovic Ananda R. Wickremasinghe Tien Yin Wong Chittaranjan S. Yajnik Salim Yusuf Habibul Ahsan Dwaipayan Bharadwaj Sonia S. Anand Jennifer E. Below Michael Boehnke Donald W. Bowden Giriraj R. Chandak Ching-Yu Cheng Norihiro Kato Anubha Mahajan Xueling Sim Mark I. McCarthy Andrew P. Morris Jaspal S. Kooner Danish Saleheen John C. Chambers |
| author_sort | Marie Loh |
| collection | DOAJ |
| description | Marie Loh, Weihua Zhang et al. use a genome-wide association study meta-analysis to examine variants associated with Type 2 diabetes (T2D) in South Asian and European ancestry cohorts. Their results provide further insights into the genetic mechanisms underlying T2D across ancestral populations. |
| first_indexed | 2024-04-13T04:22:46Z |
| format | Article |
| id | doaj.art-07ab4de945a54b4f8a1b8fb3e19f5d29 |
| institution | Directory Open Access Journal |
| issn | 2399-3642 |
| language | English |
| last_indexed | 2024-04-13T04:22:46Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Communications Biology |
| spelling | doaj.art-07ab4de945a54b4f8a1b8fb3e19f5d292022-12-22T03:02:39ZengNature PortfolioCommunications Biology2399-36422022-04-015111010.1038/s42003-022-03248-5Identification of genetic effects underlying type 2 diabetes in South Asian and European populationsMarie Loh0Weihua Zhang1Hong Kiat Ng2Katharina Schmid3Amel Lamri4Lin Tong5Meraj Ahmad6Jung-Jin Lee7Maggie C. Y. Ng8Lauren E. Petty9Cassandra N. Spracklen10Fumihiko Takeuchi11Md. Tariqul Islam12Farzana Jasmine13Anuradhani Kasturiratne14Muhammad Kibriya15Karen L. Mohlke16Guillaume Paré17Gauri Prasad18Mohammad Shahriar19Miao Ling Chee20H. Janaka de Silva21James C. Engert22Hertzel C. Gerstein23K. Radha Mani24Charumathi Sabanayagam25Marijana Vujkovic26Ananda R. Wickremasinghe27Tien Yin Wong28Chittaranjan S. Yajnik29Salim Yusuf30Habibul Ahsan31Dwaipayan Bharadwaj32Sonia S. Anand33Jennifer E. Below34Michael Boehnke35Donald W. Bowden36Giriraj R. Chandak37Ching-Yu Cheng38Norihiro Kato39Anubha Mahajan40Xueling Sim41Mark I. McCarthy42Andrew P. Morris43Jaspal S. Kooner44Danish Saleheen45John C. Chambers46Lee Kong Chian School of Medicine, Nanyang Technological UniversityDepartment of Epidemiology and Biostatistics, Imperial College LondonLee Kong Chian School of Medicine, Nanyang Technological UniversityInstitute of Computational Biology, Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum MünchenDepartment of Medicine, McMaster UniversityThe University of Chicago, Biological Sciences Division, Public Health SciencesGenomic Research on Complex diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)Translational Medicine and Human Genetics, Department of Medicine, University of PennsylvaniaCenter for Genomics and Personalized Medicine Research, Center for Diabetes Research, Wake Forest School of MedicineVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical CenterDepartment of Genetics, University of North Carolina at Chapel HillDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and MedicineU Chicago Research BangladeshThe University of Chicago, Biological Sciences Division, Public Health SciencesDepartment of Public Health, Faculty of Medicine, University of KelaniyaThe University of Chicago, Biological Sciences Division, Public Health SciencesDepartment of Genetics, University of North Carolina at Chapel HillPopulation Health Research Institute, Hamilton Health Sciences and McMaster UniversityAcademy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology CampusThe University of Chicago, Biological Sciences Division, Public Health SciencesSingapore Eye Research Institute, Singapore National Eye CentreDepartment of Medicine, Faculty of Medicine, University of KelaniyaDepartment of Medicine, McGill UniversityDepartment of Medicine, McMaster UniversityGenomic Research on Complex diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)Singapore Eye Research Institute, Singapore National Eye CentreDepartment of Biostatistics and Epidemiology, University of PennsylvaniaDepartment of Public Health, Faculty of Medicine, University of KelaniyaSingapore Eye Research Institute, Singapore National Eye CentreDiabetes Unit, King Edward Memorial Hospital and Research CentreDepartment of Medicine, McMaster UniversityThe University of Chicago, Biological Sciences Division, Public Health SciencesAcademy of Scientific and Innovative Research, CSIR-Institute of Genomics and Integrative Biology CampusDepartment of Medicine, McMaster UniversityVanderbilt Genetics Institute, Division of Genetic Medicine, Vanderbilt University Medical CenterDepartment of Biostatistics and Center for Statistical Genetics, University of MichiganDepartment of Medicine, Mayo HospitalGenomic Research on Complex diseases, CSIR-Centre for Cellular and Molecular Biology (CSIR-CCMB)Singapore Eye Research Institute, Singapore National Eye CentreDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and MedicineOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of OxfordSaw Swee Hock School of Public Health, National University of SingaporeOxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of OxfordDepartment of Biostatistics, University of LiverpoolDepartment of Cardiology, Ealing Hospital, London North West Healthcare NHS TrustCenter for Non-Communicable DiseasesLee Kong Chian School of Medicine, Nanyang Technological UniversityMarie Loh, Weihua Zhang et al. use a genome-wide association study meta-analysis to examine variants associated with Type 2 diabetes (T2D) in South Asian and European ancestry cohorts. Their results provide further insights into the genetic mechanisms underlying T2D across ancestral populations.https://doi.org/10.1038/s42003-022-03248-5 |
| spellingShingle | Marie Loh Weihua Zhang Hong Kiat Ng Katharina Schmid Amel Lamri Lin Tong Meraj Ahmad Jung-Jin Lee Maggie C. Y. Ng Lauren E. Petty Cassandra N. Spracklen Fumihiko Takeuchi Md. Tariqul Islam Farzana Jasmine Anuradhani Kasturiratne Muhammad Kibriya Karen L. Mohlke Guillaume Paré Gauri Prasad Mohammad Shahriar Miao Ling Chee H. Janaka de Silva James C. Engert Hertzel C. Gerstein K. Radha Mani Charumathi Sabanayagam Marijana Vujkovic Ananda R. Wickremasinghe Tien Yin Wong Chittaranjan S. Yajnik Salim Yusuf Habibul Ahsan Dwaipayan Bharadwaj Sonia S. Anand Jennifer E. Below Michael Boehnke Donald W. Bowden Giriraj R. Chandak Ching-Yu Cheng Norihiro Kato Anubha Mahajan Xueling Sim Mark I. McCarthy Andrew P. Morris Jaspal S. Kooner Danish Saleheen John C. Chambers Identification of genetic effects underlying type 2 diabetes in South Asian and European populations Communications Biology |
| title | Identification of genetic effects underlying type 2 diabetes in South Asian and European populations |
| title_full | Identification of genetic effects underlying type 2 diabetes in South Asian and European populations |
| title_fullStr | Identification of genetic effects underlying type 2 diabetes in South Asian and European populations |
| title_full_unstemmed | Identification of genetic effects underlying type 2 diabetes in South Asian and European populations |
| title_short | Identification of genetic effects underlying type 2 diabetes in South Asian and European populations |
| title_sort | identification of genetic effects underlying type 2 diabetes in south asian and european populations |
| url | https://doi.org/10.1038/s42003-022-03248-5 |
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