Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells
Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, fo...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2017-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00981/full |
| _version_ | 1819238023270760448 |
|---|---|
| author | Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Arshad Jamal Michelle P. Ashton Malte von Bonin Malte von Bonin Malte von Bonin Matthias Kuhn Benjamin Dorschner Dimitra Alexopoulou Katrin Navratiel Ingo Roeder Andreas Dahl Christian M. Hedrich Ezio Bonifacio Sebastian Brenner Sebastian Brenner Sebastian Thieme |
| author_facet | Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Arshad Jamal Michelle P. Ashton Malte von Bonin Malte von Bonin Malte von Bonin Matthias Kuhn Benjamin Dorschner Dimitra Alexopoulou Katrin Navratiel Ingo Roeder Andreas Dahl Christian M. Hedrich Ezio Bonifacio Sebastian Brenner Sebastian Brenner Sebastian Thieme |
| author_sort | Joanna Bandoła |
| collection | DOAJ |
| description | Plasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, for the first time, the expression and immune-regulatory function of the low affinity neurotrophin receptor p75 neurotrophin receptor (p75NTR) by the antigen-presenting pDCs, mediated by toll-like receptor (TLR) 9 activation and differential phosphorylation of interferon regulatory factor 3 and 7. The modulation of p75NTR on pDCs significantly influences disease progression of asthma in an ovalbumin-induced mouse model mediated by the TLR9 signaling pathway. p75NTR activation of pDCs from patients with asthma increased allergen-specific T cell proliferation and cytokine secretion in nerve growth factor concentration-dependent manner. Further, p75NTR activation of pDCs delayed the onset of autoimmune diabetes in RIP-CD80GP mice and aggravated graft-versus-host disease in a xenotransplantation model. Thus, p75NTR signaling on pDCs constitutes a new and critical mechanism connecting neurotrophin signaling and immune response regulation with great therapeutic potential for a variety of immune disorders. |
| first_indexed | 2024-12-23T13:29:38Z |
| format | Article |
| id | doaj.art-07ae0ebdec3f448fab222d623d00bb7b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-23T13:29:38Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-07ae0ebdec3f448fab222d623d00bb7b2022-12-21T17:45:11ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-08-01810.3389/fimmu.2017.00981276949Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic CellsJoanna Bandoła0Cornelia Richter1Martin Ryser2Arshad Jamal3Arshad Jamal4Michelle P. Ashton5Malte von Bonin6Malte von Bonin7Malte von Bonin8Matthias Kuhn9Benjamin Dorschner10Dimitra Alexopoulou11Katrin Navratiel12Ingo Roeder13Andreas Dahl14Christian M. Hedrich15Ezio Bonifacio16Sebastian Brenner17Sebastian Brenner18Sebastian Thieme19Department of Pediatrics, University Clinic Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyDepartment of Medical Laboratory Sciences, Imperial College of Business Studies, Lahore, PakistanDFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, GermanyMedical Clinic I, University Clinic Dresden, Dresden, GermanyDKTK-German Cancer Consortium, Partner Site Dresden, University Clinic Dresden, Dresden, GermanyDKFZ-German Cancer Research Center, Heidelberg, GermanyFaculty of Medicine, Institute for Medical Informatics and Biometry, Technische Universitaet Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyBIOTEChnology Center/DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyFaculty of Medicine, Institute for Medical Informatics and Biometry, Technische Universitaet Dresden, Dresden, GermanyBIOTEChnology Center/DFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyDFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyDFG-Center for Regenerative Therapies Dresden, Cluster of Excellence, Technische Universitaet Dresden, Dresden, GermanyDepartment of Pediatrics, University Clinic Dresden, Dresden, GermanyPlasmacytoid dendritic cells (pDCs) regulate innate and adaptive immunity. Neurotrophins and their receptors control the function of neuronal tissue. In addition, they have been demonstrated to be part of the immune response but little is known about the effector immune cells involved. We report, for the first time, the expression and immune-regulatory function of the low affinity neurotrophin receptor p75 neurotrophin receptor (p75NTR) by the antigen-presenting pDCs, mediated by toll-like receptor (TLR) 9 activation and differential phosphorylation of interferon regulatory factor 3 and 7. The modulation of p75NTR on pDCs significantly influences disease progression of asthma in an ovalbumin-induced mouse model mediated by the TLR9 signaling pathway. p75NTR activation of pDCs from patients with asthma increased allergen-specific T cell proliferation and cytokine secretion in nerve growth factor concentration-dependent manner. Further, p75NTR activation of pDCs delayed the onset of autoimmune diabetes in RIP-CD80GP mice and aggravated graft-versus-host disease in a xenotransplantation model. Thus, p75NTR signaling on pDCs constitutes a new and critical mechanism connecting neurotrophin signaling and immune response regulation with great therapeutic potential for a variety of immune disorders.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00981/fullplasmacytoid dendritic cellsp75 neurotrophin receptorneurotrophinTLR9autoimmune diabetesgraft-versus-host disease |
| spellingShingle | Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Arshad Jamal Michelle P. Ashton Malte von Bonin Malte von Bonin Malte von Bonin Matthias Kuhn Benjamin Dorschner Dimitra Alexopoulou Katrin Navratiel Ingo Roeder Andreas Dahl Christian M. Hedrich Ezio Bonifacio Sebastian Brenner Sebastian Brenner Sebastian Thieme Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells Frontiers in Immunology plasmacytoid dendritic cells p75 neurotrophin receptor neurotrophin TLR9 autoimmune diabetes graft-versus-host disease |
| title | Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells |
| title_full | Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells |
| title_fullStr | Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells |
| title_full_unstemmed | Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells |
| title_short | Neurotrophin Receptor p75NTR Regulates Immune Function of Plasmacytoid Dendritic Cells |
| title_sort | neurotrophin receptor p75ntr regulates immune function of plasmacytoid dendritic cells |
| topic | plasmacytoid dendritic cells p75 neurotrophin receptor neurotrophin TLR9 autoimmune diabetes graft-versus-host disease |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00981/full |
| work_keys_str_mv | AT joannabandoła neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT corneliarichter neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT martinryser neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT arshadjamal neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT arshadjamal neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT michellepashton neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT maltevonbonin neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT maltevonbonin neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT maltevonbonin neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT matthiaskuhn neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT benjamindorschner neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT dimitraalexopoulou neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT katrinnavratiel neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT ingoroeder neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT andreasdahl neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT christianmhedrich neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT eziobonifacio neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT sebastianbrenner neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT sebastianbrenner neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells AT sebastianthieme neurotrophinreceptorp75ntrregulatesimmunefunctionofplasmacytoiddendriticcells |