Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study
Living systems display a variety of situations in which non-equilibrium fluctuations couple to certain protein functions yielding astonishing results. Here we study the bacterial channel OmpF under conditions similar to those met in vivo, where acidic resistance mechanisms are known to yield oscilla...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2017-03-01
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| Series: | Entropy |
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| Online Access: | http://www.mdpi.com/1099-4300/19/3/116 |
| _version_ | 1798003596080447488 |
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| author | Marcel Aguilella-Arzo María Queralt-Martín María-Lidón Lopez Antonio Alcaraz |
| author_facet | Marcel Aguilella-Arzo María Queralt-Martín María-Lidón Lopez Antonio Alcaraz |
| author_sort | Marcel Aguilella-Arzo |
| collection | DOAJ |
| description | Living systems display a variety of situations in which non-equilibrium fluctuations couple to certain protein functions yielding astonishing results. Here we study the bacterial channel OmpF under conditions similar to those met in vivo, where acidic resistance mechanisms are known to yield oscillations in the electric potential across the cell membrane. We use a three-dimensional structure-based theoretical approach to assess the possibility of obtaining fluctuation-driven transport. Our calculations show that remarkably high voltages would be necessary to observe the actual transport of ions against their concentration gradient. The reasons behind this are the mild selectivity of this bacterial pore and the relatively low efficiencies of the oscillating signals characteristic of membrane cells (random telegraph noise and thermal noise). |
| first_indexed | 2024-04-11T12:10:14Z |
| format | Article |
| id | doaj.art-07ae7a80829c48a6b76b5ae7f509cfff |
| institution | Directory Open Access Journal |
| issn | 1099-4300 |
| language | English |
| last_indexed | 2024-04-11T12:10:14Z |
| publishDate | 2017-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Entropy |
| spelling | doaj.art-07ae7a80829c48a6b76b5ae7f509cfff2022-12-22T04:24:38ZengMDPI AGEntropy1099-43002017-03-0119311610.3390/e19030116e19030116Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck StudyMarcel Aguilella-Arzo0María Queralt-Martín1María-Lidón Lopez2Antonio Alcaraz3Laboratory of Molecular Biophysics, Department of Physics, Universitat Jaume I, Av. Vicent Sos Baynat s/n, 12071 Castellón, SpainLaboratory of Molecular Biophysics, Department of Physics, Universitat Jaume I, Av. Vicent Sos Baynat s/n, 12071 Castellón, SpainLaboratory of Molecular Biophysics, Department of Physics, Universitat Jaume I, Av. Vicent Sos Baynat s/n, 12071 Castellón, SpainLaboratory of Molecular Biophysics, Department of Physics, Universitat Jaume I, Av. Vicent Sos Baynat s/n, 12071 Castellón, SpainLiving systems display a variety of situations in which non-equilibrium fluctuations couple to certain protein functions yielding astonishing results. Here we study the bacterial channel OmpF under conditions similar to those met in vivo, where acidic resistance mechanisms are known to yield oscillations in the electric potential across the cell membrane. We use a three-dimensional structure-based theoretical approach to assess the possibility of obtaining fluctuation-driven transport. Our calculations show that remarkably high voltages would be necessary to observe the actual transport of ions against their concentration gradient. The reasons behind this are the mild selectivity of this bacterial pore and the relatively low efficiencies of the oscillating signals characteristic of membrane cells (random telegraph noise and thermal noise).http://www.mdpi.com/1099-4300/19/3/116non-equilibrium fluctuationsion transportbiological channelelectrodiffusioncomputational biophysics |
| spellingShingle | Marcel Aguilella-Arzo María Queralt-Martín María-Lidón Lopez Antonio Alcaraz Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study Entropy non-equilibrium fluctuations ion transport biological channel electrodiffusion computational biophysics |
| title | Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study |
| title_full | Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study |
| title_fullStr | Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study |
| title_full_unstemmed | Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study |
| title_short | Fluctuation-Driven Transport in Biological Nanopores. A 3D Poisson–Nernst–Planck Study |
| title_sort | fluctuation driven transport in biological nanopores a 3d poisson nernst planck study |
| topic | non-equilibrium fluctuations ion transport biological channel electrodiffusion computational biophysics |
| url | http://www.mdpi.com/1099-4300/19/3/116 |
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