Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy
Engineering and application of nanomaterials have recently helped advance various biomedical fields. Zinc oxide (ZnO)-based nanocomposites have become one of the most promising candidates for biomedical applications due to their biocompatibility, unique physicochemical properties, and cost-effective...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-09-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/11/10/493 |
| _version_ | 1828276722776145920 |
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| author | Prashant Sharma Na-Yoon Jang Jae-Won Lee Bum Chul Park Young Keun Kim Nam-Hyuk Cho |
| author_facet | Prashant Sharma Na-Yoon Jang Jae-Won Lee Bum Chul Park Young Keun Kim Nam-Hyuk Cho |
| author_sort | Prashant Sharma |
| collection | DOAJ |
| description | Engineering and application of nanomaterials have recently helped advance various biomedical fields. Zinc oxide (ZnO)-based nanocomposites have become one of the most promising candidates for biomedical applications due to their biocompatibility, unique physicochemical properties, and cost-effective mass production. In addition, recent advances in nano-engineering technologies enable the generation of ZnO nanocomposites with unique three-dimensional structures and surface characteristics that are optimally designed for in vivo applications. Here, we review recent advances in the application of diverse ZnO nanocomposites, with an especial focus on their development as vaccine adjuvant and cancer immunotherapeutics, as well as their intrinsic properties interacting with the immune system and potential toxic effect in vivo. Finally, we summarize promising proof-of-concept applications as prophylactic and therapeutic vaccines against infections and cancers. Understanding the nano-bio interfaces between ZnO-based nanocomposites and the immune system, together with bio-effective design of the nanomaterial using nano-architectonic technology, may open new avenues in expanding the biomedical application of ZnO nanocomposites as a novel vaccine platform. |
| first_indexed | 2024-04-13T07:01:41Z |
| format | Article |
| id | doaj.art-07afd9ed216844909f52c28123918f0b |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-13T07:01:41Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-07afd9ed216844909f52c28123918f0b2022-12-22T02:57:05ZengMDPI AGPharmaceutics1999-49232019-09-01111049310.3390/pharmaceutics11100493pharmaceutics11100493Application of ZnO-Based Nanocomposites for Vaccines and Cancer ImmunotherapyPrashant Sharma0Na-Yoon Jang1Jae-Won Lee2Bum Chul Park3Young Keun Kim4Nam-Hyuk Cho5Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03080, KoreaDepartment of Materials Science and Engineering, Korea University, Seoul 02841, KoreaDepartment of Materials Science and Engineering, Korea University, Seoul 02841, KoreaDepartment of Microbiology and Immunology, Seoul National University College of Medicine, Seoul 03080, KoreaEngineering and application of nanomaterials have recently helped advance various biomedical fields. Zinc oxide (ZnO)-based nanocomposites have become one of the most promising candidates for biomedical applications due to their biocompatibility, unique physicochemical properties, and cost-effective mass production. In addition, recent advances in nano-engineering technologies enable the generation of ZnO nanocomposites with unique three-dimensional structures and surface characteristics that are optimally designed for in vivo applications. Here, we review recent advances in the application of diverse ZnO nanocomposites, with an especial focus on their development as vaccine adjuvant and cancer immunotherapeutics, as well as their intrinsic properties interacting with the immune system and potential toxic effect in vivo. Finally, we summarize promising proof-of-concept applications as prophylactic and therapeutic vaccines against infections and cancers. Understanding the nano-bio interfaces between ZnO-based nanocomposites and the immune system, together with bio-effective design of the nanomaterial using nano-architectonic technology, may open new avenues in expanding the biomedical application of ZnO nanocomposites as a novel vaccine platform.https://www.mdpi.com/1999-4923/11/10/493zno nanocompositevaccinecancerimmunotherapytoxicityimmune cells |
| spellingShingle | Prashant Sharma Na-Yoon Jang Jae-Won Lee Bum Chul Park Young Keun Kim Nam-Hyuk Cho Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy Pharmaceutics zno nanocomposite vaccine cancer immunotherapy toxicity immune cells |
| title | Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy |
| title_full | Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy |
| title_fullStr | Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy |
| title_full_unstemmed | Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy |
| title_short | Application of ZnO-Based Nanocomposites for Vaccines and Cancer Immunotherapy |
| title_sort | application of zno based nanocomposites for vaccines and cancer immunotherapy |
| topic | zno nanocomposite vaccine cancer immunotherapy toxicity immune cells |
| url | https://www.mdpi.com/1999-4923/11/10/493 |
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