Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice

Deficiency in hormone-sensitive lipase accelerates the development of pancreatic cancer in conditional KrasG12D mice

Abstract Background Hormone sensitive lipase (HSL) is a neutral lipase that preferentially catalyzes the hydrolysis of diacylglycerol contributing to triacylglycerol breakdown in the adipose tissue. HSL has been implicated to play a role in tumor cachexia, a debilitating syndrome characterized by pr...

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Bibliographic Details
Main Authors: Mu Xu, Hui-Hua Chang, Xiaoman Jung, Aune Moro, Caroline Ei Ne Chou, Jonathan King, O. Joe Hines, James Sinnett-Smith, Enrique Rozengurt, Guido Eibl
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Cancer
Subjects:
Pancreatic cancer
Hormone sensitive lipase
Adipose tissue inflammation
Pancreatic inflammation
Animal model
Online Access:http://link.springer.com/article/10.1186/s12885-018-4713-y

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