Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk
Introduction: Organochlorine pesticides (OCPs) can increase the production of reactive oxygen species (ROS), the effects of which can be countered by the antioxidant system, also present in breast milk. Objective: To evaluate the indicators of oxidative stress in breast milk associated to the presen...
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| Format: | Article |
| Language: | English |
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Arán Ediciones, S. L.
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| Series: | Nutrición Hospitalaria |
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| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200038&lng=en&tlng=en |
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| author | Patricia Carolina Castillo-Castañeda Ramón Gaxiola-Robles Lía Celina Méndez-Rodríguez Vanessa Labrada-Martagón Tania Zenteno-Savín |
| author_facet | Patricia Carolina Castillo-Castañeda Ramón Gaxiola-Robles Lía Celina Méndez-Rodríguez Vanessa Labrada-Martagón Tania Zenteno-Savín |
| author_sort | Patricia Carolina Castillo-Castañeda |
| collection | DOAJ |
| description | Introduction: Organochlorine pesticides (OCPs) can increase the production of reactive oxygen species (ROS), the effects of which can be countered by the antioxidant system, also present in breast milk. Objective: To evaluate the indicators of oxidative stress in breast milk associated to the presence of OCPs, and their relationship with seafood intake. Methods: Breast milk was collected from 108 lactating women. Indicators of oxidative stress (antioxidant enzyme activity, glutathione concentration, superoxide radical [O2•-] production, lipid peroxidation and carbonylated protein concentration) were analyzed by spectrophotometry. OCPs concentrations were measured by gas chromatography. Results and discussion: O2•- production had no significant relationship with OCPs concentrations. Significant correlations between OCPs concentrations and antioxidant enzyme activities (glutathione reductase [GR] activity and aldrin concentration [r = - 0.5], superoxide dismutase [SOD] activity and α-HCH concentration [r = 0.45]) were found. Oxidative damage had a low correlation with OCPs content (r < 0.30, p < 0.05). It is possible that OCP's levels are not sufficient to increase O2•- production, that production of ROS other than O2•- is increased, or that the antioxidant capacity is sufficient to avoid oxidative damage in breast milk. Conclusion: Results from this study suggest that marine diet is not a determinant factor in the level of contamination by OCP's or in the oxidative damage in breast milk. |
| first_indexed | 2024-12-10T06:30:00Z |
| format | Article |
| id | doaj.art-07b0827dcf6c4cfc92df4d3fc604de5e |
| institution | Directory Open Access Journal |
| issn | 0212-1611 |
| language | English |
| last_indexed | 2024-12-10T06:30:00Z |
| publisher | Arán Ediciones, S. L. |
| record_format | Article |
| series | Nutrición Hospitalaria |
| spelling | doaj.art-07b0827dcf6c4cfc92df4d3fc604de5e2022-12-22T01:59:07ZengArán Ediciones, S. L.Nutrición Hospitalaria0212-161133242243010.20960/nh.127S0212-16112016000200038Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milkPatricia Carolina Castillo-Castañeda0Ramón Gaxiola-Robles1Lía Celina Méndez-Rodríguez2Vanessa Labrada-Martagón3Tania Zenteno-Savín4Centro de Investigaciones Biológicas del Noroeste, S.C. (CIBNOR)Centro de Investigaciones Biológicas del Noroeste, S.C. (CIBNOR)Centro de Investigaciones Biológicas del Noroeste, S.C. (CIBNOR)Centro de Investigaciones Biológicas del Noroeste, S.C. (CIBNOR)Centro de Investigaciones Biológicas del Noroeste, S.C. (CIBNOR)Introduction: Organochlorine pesticides (OCPs) can increase the production of reactive oxygen species (ROS), the effects of which can be countered by the antioxidant system, also present in breast milk. Objective: To evaluate the indicators of oxidative stress in breast milk associated to the presence of OCPs, and their relationship with seafood intake. Methods: Breast milk was collected from 108 lactating women. Indicators of oxidative stress (antioxidant enzyme activity, glutathione concentration, superoxide radical [O2•-] production, lipid peroxidation and carbonylated protein concentration) were analyzed by spectrophotometry. OCPs concentrations were measured by gas chromatography. Results and discussion: O2•- production had no significant relationship with OCPs concentrations. Significant correlations between OCPs concentrations and antioxidant enzyme activities (glutathione reductase [GR] activity and aldrin concentration [r = - 0.5], superoxide dismutase [SOD] activity and α-HCH concentration [r = 0.45]) were found. Oxidative damage had a low correlation with OCPs content (r < 0.30, p < 0.05). It is possible that OCP's levels are not sufficient to increase O2•- production, that production of ROS other than O2•- is increased, or that the antioxidant capacity is sufficient to avoid oxidative damage in breast milk. Conclusion: Results from this study suggest that marine diet is not a determinant factor in the level of contamination by OCP's or in the oxidative damage in breast milk.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200038&lng=en&tlng=enAntioxidantesDieta marinaPlaguicidas organoclorados |
| spellingShingle | Patricia Carolina Castillo-Castañeda Ramón Gaxiola-Robles Lía Celina Méndez-Rodríguez Vanessa Labrada-Martagón Tania Zenteno-Savín Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk Nutrición Hospitalaria Antioxidantes Dieta marina Plaguicidas organoclorados |
| title | Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk |
| title_full | Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk |
| title_fullStr | Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk |
| title_full_unstemmed | Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk |
| title_short | Antioxidants, reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk |
| title_sort | antioxidants reactive oxygen species and oxidative damage associated to the presence of organochlorine pesticides in breast milk |
| topic | Antioxidantes Dieta marina Plaguicidas organoclorados |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S0212-16112016000200038&lng=en&tlng=en |
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