Validation of the Filovirus Plaque Assay for Use in Preclinical Studies

Validation of the Filovirus Plaque Assay for Use in Preclinical Studies

A plaque assay for quantitating filoviruses in virus stocks, prepared viral challenge inocula and samples from research animals has recently been fully characterized and standardized for use across multiple institutions performing Biosafety Level 4 (BSL-4) studies. After standardization studies were...

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Bibliographic Details
Main Authors: Amy C. Shurtleff, Holly A. Bloomfield, Shannon Mort, Steven A. Orr, Brian Audet, Thomas Whitaker, Michelle J. Richards, Sina Bavari
Format: Article
Language:English
Published: MDPI AG 2016-04-01
Series:Viruses
Subjects:
plaque assay
filovirus
Ebola
ebolavirus
Marburgvirus
Marburg virus
Vero E6 cells
GLP compliant
validation
animal rule
Online Access:http://www.mdpi.com/1999-4915/8/4/113

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