Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight
Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of developmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating f...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023043384 |
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| author | David Szaraz Zdenek Danek Bretislav Lipovy Jan Krivanek Marcela Buchtova Barbora Moldovan Putnova Iveta Putnova Jan Stembirek Tomas Andrasina Petra Divacka Lydie Izakovicova Holla Petra Borilova Linhartova |
| author_facet | David Szaraz Zdenek Danek Bretislav Lipovy Jan Krivanek Marcela Buchtova Barbora Moldovan Putnova Iveta Putnova Jan Stembirek Tomas Andrasina Petra Divacka Lydie Izakovicova Holla Petra Borilova Linhartova |
| author_sort | David Szaraz |
| collection | DOAJ |
| description | Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of developmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating from the autosomal dominant polycystic kidney disease (ADPKD) has been, however, explored in much greater detail. This narrative review aimed i) to summarize molecular and cellular processes involved in the formation and growth of developmental OCs, especially dentigerous cysts (DCs) and odontogenic keratocysts (OKCs), ii) to find if there are any similarities in their cystogenesis to ADPKD cysts, and, based on that, iii) to suggest potential factors, candidate molecules, and mechanisms that could be involved in the DC formation, thus proposing further research directions. Here we suggest a possible association of developmental OCs with primary cilia disruption and with hypoxia, which have been previously linked with cyst formation in ADPKD patients. This is illustrated on the imagery of tissues from an ADPKD patient (renal cyst) and from developmental OCs, supporting the similarities in cell proliferation, apoptosis, and primary cilia distribution in DC/OKC/ADPKD tissues. Based on all that, we propose a novel hypothesis of OCs formation suggesting a crucial role of mutations associated with the signaling pathways of primary cilia (in particular, Sonic Hedgehog). These can lead to excessive proliferation and formation of cell agglomerates, which is followed by hypoxia-driven apoptosis in the centers of such agglomerates (controlled by molecules such as Hypoxia-inducible factor-1 alpha), leading to cavity formation and, finally, the OCs development. Based on this, we propose future perspectives in the investigation of OC pathogenesis. |
| first_indexed | 2024-03-13T04:43:01Z |
| format | Article |
| id | doaj.art-07b3c32fae074573ba8c9a61af17609e |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-13T04:43:01Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-07b3c32fae074573ba8c9a61af17609e2023-06-19T04:29:08ZengElsevierHeliyon2405-84402023-06-0196e17130Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insightDavid Szaraz0Zdenek Danek1Bretislav Lipovy2Jan Krivanek3Marcela Buchtova4Barbora Moldovan Putnova5Iveta Putnova6Jan Stembirek7Tomas Andrasina8Petra Divacka9Lydie Izakovicova Holla10Petra Borilova Linhartova11Clinic of Maxillofacial Surgery, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic; Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech RepublicClinic of Maxillofacial Surgery, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic; Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech RepublicFaculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic; Department of Burns and Plastic Surgery, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech RepublicDepartment of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech RepublicLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Veveří 97, 602 00 Brno, Czech Republic; Department of Experimental Biology, Faculty of Science, Masaryk University, Kamenice 5, 62500 Brno, Czech RepublicLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Veveří 97, 602 00 Brno, Czech Republic; Department of Pathological Morphology and Parasitology, University of Veterinary Sciences, Palackého tř. 1946/1, 61242 Brno-Královo Pole, Czech RepublicLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Veveří 97, 602 00 Brno, Czech Republic; Department of Anatomy, Histology and Embryology, University of Veterinary and Pharmaceutical Sciences, Palackého tř. 1946/1, 61242 Brno-Královo Pole, Czech RepublicLaboratory of Molecular Morphogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Veveří 97, 602 00 Brno, Czech Republic; Clinic of Maxillofacial Surgery, University Hospital Ostrava, 17. Listopadu 1790/5, 70800 Ostrava-Poruba, Czech RepublicFaculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic; Department of Radiology and Nuclear Medicine, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech RepublicFaculty of Medicine, Masaryk University, Kamenice 5, 62500 Brno, Czech Republic; Department of Internal Medicine and Gastroenterology, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech RepublicClinic of Stomatology, Institution Shared with St. Anne’s University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200 Brno, Czech RepublicClinic of Maxillofacial Surgery, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic; Clinic of Stomatology, Institution Shared with St. Anne’s University Hospital, Faculty of Medicine, Masaryk University, Pekarska 664/53, 60200 Brno, Czech Republic; RECETOX, Faculty of Science, Masaryk University, Kotlarska 2, Brno, Czech Republic; Corresponding author. Head of the Environmental Genomics Research Group, RECETOX, Faculty of Science, Masaryk University, Kamenice 5, 6250 00 Brno, Czech Republic.Developmental cysts are pathological epithelial-lined cavities arising in various organs as a result of systemic or hereditary diseases. Molecular mechanisms involved in the formation of developmental odontogenic cysts (OCs) are not fully understood yet; the cystogenesis of renal cysts originating from the autosomal dominant polycystic kidney disease (ADPKD) has been, however, explored in much greater detail. This narrative review aimed i) to summarize molecular and cellular processes involved in the formation and growth of developmental OCs, especially dentigerous cysts (DCs) and odontogenic keratocysts (OKCs), ii) to find if there are any similarities in their cystogenesis to ADPKD cysts, and, based on that, iii) to suggest potential factors, candidate molecules, and mechanisms that could be involved in the DC formation, thus proposing further research directions. Here we suggest a possible association of developmental OCs with primary cilia disruption and with hypoxia, which have been previously linked with cyst formation in ADPKD patients. This is illustrated on the imagery of tissues from an ADPKD patient (renal cyst) and from developmental OCs, supporting the similarities in cell proliferation, apoptosis, and primary cilia distribution in DC/OKC/ADPKD tissues. Based on all that, we propose a novel hypothesis of OCs formation suggesting a crucial role of mutations associated with the signaling pathways of primary cilia (in particular, Sonic Hedgehog). These can lead to excessive proliferation and formation of cell agglomerates, which is followed by hypoxia-driven apoptosis in the centers of such agglomerates (controlled by molecules such as Hypoxia-inducible factor-1 alpha), leading to cavity formation and, finally, the OCs development. Based on this, we propose future perspectives in the investigation of OC pathogenesis.http://www.sciencedirect.com/science/article/pii/S2405844023043384Developmental odontogenic cystDentigerous cystOdontogenic keratocystPolycystic kidney diseasePrimary ciliaSonic hedgehog pathway |
| spellingShingle | David Szaraz Zdenek Danek Bretislav Lipovy Jan Krivanek Marcela Buchtova Barbora Moldovan Putnova Iveta Putnova Jan Stembirek Tomas Andrasina Petra Divacka Lydie Izakovicova Holla Petra Borilova Linhartova Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight Heliyon Developmental odontogenic cyst Dentigerous cyst Odontogenic keratocyst Polycystic kidney disease Primary cilia Sonic hedgehog pathway |
| title | Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight |
| title_full | Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight |
| title_fullStr | Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight |
| title_full_unstemmed | Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight |
| title_short | Primary cilia and hypoxia-associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease – A novel insight |
| title_sort | primary cilia and hypoxia associated signaling in developmental odontogenic cysts in relation to autosomal dominant polycystic kidney disease a novel insight |
| topic | Developmental odontogenic cyst Dentigerous cyst Odontogenic keratocyst Polycystic kidney disease Primary cilia Sonic hedgehog pathway |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023043384 |
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