Selenium: An Antioxidant with a Critical Role in Anti-Aging
Aging is characterized by an imbalance between damage inflicted by reactive oxygen species (ROS) and the antioxidative defenses of the organism. As a significant nutritional factor, the trace element selenium (Se) may remodel gradual and spontaneous physiological changes caused by oxidative stress,...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/19/6613 |
| _version_ | 1827653695429410816 |
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| author | Geir Bjørklund Mariia Shanaida Roman Lysiuk Halyna Antonyak Ivan Klishch Volodymyr Shanaida Massimiliano Peana |
| author_facet | Geir Bjørklund Mariia Shanaida Roman Lysiuk Halyna Antonyak Ivan Klishch Volodymyr Shanaida Massimiliano Peana |
| author_sort | Geir Bjørklund |
| collection | DOAJ |
| description | Aging is characterized by an imbalance between damage inflicted by reactive oxygen species (ROS) and the antioxidative defenses of the organism. As a significant nutritional factor, the trace element selenium (Se) may remodel gradual and spontaneous physiological changes caused by oxidative stress, potentially leading to disease prevention and healthy aging. Se is involved in improving antioxidant defense, immune functions, and metabolic homeostasis. An inadequate Se status may reduce human life expectancy by accelerating the aging process or increasing vulnerability to various disorders, including immunity dysfunction, and cancer risk. This review highlights the available studies on the effective role of Se in aging mechanisms and shows the potential clinical implications related to its consumption. The main sources of organic Se and the advantages of its nanoformulations were also discussed. |
| first_indexed | 2024-03-09T21:23:20Z |
| format | Article |
| id | doaj.art-07b44473dc2340a8aaa8b0e3bd96cb88 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T21:23:20Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-07b44473dc2340a8aaa8b0e3bd96cb882023-11-23T21:14:19ZengMDPI AGMolecules1420-30492022-10-012719661310.3390/molecules27196613Selenium: An Antioxidant with a Critical Role in Anti-AgingGeir Bjørklund0Mariia Shanaida1Roman Lysiuk2Halyna Antonyak3Ivan Klishch4Volodymyr Shanaida5Massimiliano Peana6Council for Nutritional and Environmental Medicine (CONEM), Toften 24, 8610 Mo i Rana, NorwayI. Horbachevsky Ternopil National Medical University, 46001 Ternopil, UkraineDepartment of Pharmacognosy and Botany, Danylo Halytsky Lviv National Medical University, 79010 Lviv, UkraineDepartment of Ecology, Ivan Franko National University of Lviv, 79005 Lviv, UkraineI. Horbachevsky Ternopil National Medical University, 46001 Ternopil, UkraineDesign of Machine Tools, Instruments and Machines Department, Ternopil Ivan Puluj National Technical University, 46001 Ternopil, UkraineDepartment of Chemical, Physics, Mathematics and Natural Sciences, University of Sassari, 07100 Sassari, ItalyAging is characterized by an imbalance between damage inflicted by reactive oxygen species (ROS) and the antioxidative defenses of the organism. As a significant nutritional factor, the trace element selenium (Se) may remodel gradual and spontaneous physiological changes caused by oxidative stress, potentially leading to disease prevention and healthy aging. Se is involved in improving antioxidant defense, immune functions, and metabolic homeostasis. An inadequate Se status may reduce human life expectancy by accelerating the aging process or increasing vulnerability to various disorders, including immunity dysfunction, and cancer risk. This review highlights the available studies on the effective role of Se in aging mechanisms and shows the potential clinical implications related to its consumption. The main sources of organic Se and the advantages of its nanoformulations were also discussed.https://www.mdpi.com/1420-3049/27/19/6613seleniumhealth benefithuman agingantioxidant effectimmunoprotectionchemoprevention |
| spellingShingle | Geir Bjørklund Mariia Shanaida Roman Lysiuk Halyna Antonyak Ivan Klishch Volodymyr Shanaida Massimiliano Peana Selenium: An Antioxidant with a Critical Role in Anti-Aging Molecules selenium health benefit human aging antioxidant effect immunoprotection chemoprevention |
| title | Selenium: An Antioxidant with a Critical Role in Anti-Aging |
| title_full | Selenium: An Antioxidant with a Critical Role in Anti-Aging |
| title_fullStr | Selenium: An Antioxidant with a Critical Role in Anti-Aging |
| title_full_unstemmed | Selenium: An Antioxidant with a Critical Role in Anti-Aging |
| title_short | Selenium: An Antioxidant with a Critical Role in Anti-Aging |
| title_sort | selenium an antioxidant with a critical role in anti aging |
| topic | selenium health benefit human aging antioxidant effect immunoprotection chemoprevention |
| url | https://www.mdpi.com/1420-3049/27/19/6613 |
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