Alpha Adrenergic Induction of Transport of Lysosomal Enzyme across the Blood-Brain Barrier.
The impermeability of the adult blood-brain barrier (BBB) to lysosomal enzymes impedes the ability to treat the central nervous system manifestations of lysosomal storage diseases. Here, we found that simultaneous stimulation of the alpha1 and alpha2 adrenoreceptor restores in adult mice the high ra...
| Hauptverfasser: | , , , , , |
|---|---|
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
Public Library of Science (PLoS)
2015-01-01
|
| Schriftenreihe: | PLoS ONE |
| Online Zugang: | http://europepmc.org/articles/PMC4636227?pdf=render |