Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

Genetic predictions of height differ among human populations and these differences have been interpreted as evidence of polygenic adaptation. These differences were first detected using SNPs genome-wide significantly associated with height, and shown to grow stronger when large numbers of sub-signif...

Full description

Bibliographic Details
Main Authors: Mashaal Sohail, Robert M Maier, Andrea Ganna, Alex Bloemendal, Alicia R Martin, Michael C Turchin, Charleston WK Chiang, Joel Hirschhorn, Mark J Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil R Sunyaev
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-03-01
Series:eLife
Subjects:
polygenic adaptation
selection for human height
population stratification
GWAS
Online Access:https://elifesciences.org/articles/39702

Internet

https://elifesciences.org/articles/39702

Similar Items